A crucial element in the development of topical and transdermal drug products is evaluation of the percutaneous absorption of the active pharmaceutical ingredient (API). Generally, the goal for topical products is to maximize cutaneous delivery of the API, whereas for transdermal products the goal is to achieve a specific rate of absorption sufficient to achieve a systemic blood level within the ...
Three-phase partitioning (TPP) represents an incredibly simple, rapid method for extracting, purifying and concentrating proteins for use as either a protein mini-prep kit or scaled up to large manufacturing operations. Three-phase partitioning (TPP) is a relatively new, three-stage, batch method for rapidly and effectively purifying proteins (1,2). The TPP method may be used as a protein ...
Throughout the economic downturn of 2008 and 2009, which dramatically impacted IT service spending, the Business Intelligence (BI) market remained a bright spot. In fact, many vendors experienced double-digit or even triple-digit growth of BI-related services in 2009, while experiencing revenue declines through the remainder of their portfolios.
Challenging economic times have created the need ...
Accurate measurement of immune activity in relation to therapeutic dosing is an important part of many clinical trials, yet is poorly addressed by traditional techniques. Typical immune activity monitoring is performed using isolated leukocytes or even sorted sub- population culturing methods followed by an analytical measurement. These methods require the shipment of intact blood samples to a ...
Over the past decade, seven best practices studies in the arena of HR development have documented the growing professionalism of corporate efforts in leadership development. In APQC's most recent study, we found fewer new concepts and tools but much more alignment and consistent use of the basics than we saw in previous projects. The distinctive quality of our best‐practice partners was more in ...
Process variability is a leading cause in biopharmaceutical batch failure and impacts the value and profitability of the industry. Thermo Fisher Scientific controls inherent variability through the use of the Thermo Scientific Antaris line of Fourier transform near-infrared (FT-NIR) spectrometers.
To show that Minncare is effective against other microorganisms, the following in vitro tests were performed using a .5% solution of Minncare. All tests were done on aqueous test solutions at 20°C.
On the surface, providing a specified humidity and temperature for stability testing may appear easier to achieve than the 5% RH and 2C ICH guidelines would seem to indicate. The ability to control humidity at 2% does not mean that you are safely within the 5% RH tolerance dictated by ICH.
The ability to produce a recording, display, or printout that is within a specified tolerance may not be a ...
Cyclooxygenases (COXs), also known as prostaglandin H synthases, are fatty acid oxygenases that contain about 600 amino acid residues and act on arachidonic acid to generate prostaglandins (PG). All vertebrates contain two COX genes: one encoding the constitutive COX-1 and another inducible COX-2. COX-1 and COX-2 share approximately 60-65% amino acid identity. These COX isoforms are bifunctional ...
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