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Patheon Inc.	Engineering of Pharmaceutical Materials: An Industrial Perspective Crystal engineering provides a rational approach to solving formulation, processing and product performance problems. This review discusses how the concept of crystal engineering can be judiciously utilized to manipulate the solid-state properties of drugs and excipients for successful pharmaceutical formulation and process development. Existing and emerging manufacturing as well as ...

Brighter Ideas, Inc.	Protein Purification - in Current Analytical Chemistry, 2009 The science, art, and practice of protein purification have been with us for more than a century, yet, in many respects, the field is only now evolving past its adolescent roots. New methods are replacing old methods at such a dizzying pace, that even life-long experts in protein purification cannot keep up. In this article, we present many state-of-the-art protein purification techniques ...

Advantage MS	Be the Cheetah Over the past several years people have become increasingly more conscious about the impact of their actions. This shift in how we view things has been largely awakened by economics and is also the case within the business world. What is success and how do you define it? At times success can be difficult to recognize and how you define success has a major impact on the decisions you ...

BioClinica, Inc.	FDA Response to Adverse Event Issues In the wake of the recent spate of drug withdrawals and other drug safety issues, there have been renewed calls to reform and enhance the U.S. approach to monitoring safety issues in marketed products. These calls have come from many quarters, and a variety of initiatives have been the result.

United States Biological	IHC General Protocols Immunohistochemistry is widely used in basic research to understand the distribution and localization of biomarkers and differentially expressed proteins in different parts of a biological tissue. IHC staining is also widely used in the diagnosis of abnormal cells such as those found in cancerous tumors. Visualizing an antibody-antigen interaction can be accomplished in a number of ways. In the ...

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Pharmaceuticals Research Library

Parameter Generation & Control, Inc.	Issues to Consider When Complying With ICH Guidelines Involving Temperature and ... On the surface, providing a specified humidity and temperature for stability testing may appear easier to achieve than the 5% RH and 2C ICH guidelines would seem to indicate. The ability to control humidity at 2% does not mean that you are safely within the 5% RH tolerance dictated by ICH. The ability to produce a recording, display, or printout that is within a specified tolerance may not be a ...

EMD Chemicals Inc.	Telomere, Telomerase, and Cellular Senescence and Death Telomerase is a specialized ribonucleoprotein composed of telomerase reverse transcriptase (TERT), an intrinsic RNA template (TR), and several associated proteins. Its main function is to stabilize telomeres, which protect chromosomes from recombination and end-to-end fusion. Telomeres also recognize DNA damage and control the replicative capability of cells. With each cell division some of ...

Mar Cor Purification	Research Topic: Actril Cold Sterilant and Surface Challenge Test (USP <1072>) Actril Cold Sterilant is an US EPA registered disinfectant that has a broad range of disinfection claims. Actril Cold Steril- ant is used in a wide range of healthcare and clean room facilities. This technical white paper examines the use of Actril Cold Sterilant in a pharmaceutical manufacturing en- vironment that complies with USP-NF <1072>: Disinfectants and Antiseptics. Actril Cold Sterilant ...

Pace Analytical Life Sciences, LLC	Headspace Moisture Analysis in Medical Device Packages

Thermo Scientific Cell Culture and Bioprocessing	How WDS and Parallel Beam Spectroscopy Work X-ray microanalysis on the scanning electron microscope (SEM) is accomplished using either Energy Dispersive Spectrometry (EDS) or Wavelength Dispersive Spectroscopy (WDS). EDS developed in the early 1970 is a flexible elemental analysis method used for qualitative and quantitative composition determinations of solid, liquid, thin film and powder samples. The overlap of analyte peaks in complex ...

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BioClinica, Inc.	BioClinica Trial Blazers Supply Chain Managment BioClinica's thought leaders speak out on hot clinical supply chain topics.

Thermo Scientific Portal Optical Analyzers	Thermo Scientific TruScan The TruScan analyzer is the leading handheld Raman system for rapid, cost-effective material identity verification.

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