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Bioanalytical Systems
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BASi has developed a sensitive, specific and robust method for detecting and quantifying oxycodone and its two major metabolites, noroxycodone and oxymorphone, in human plasma. The assay is performed using LC-MS/MS to quantify these analytes along with three isotopically-substituted internal standards, d oxycodone, d oxymorphone and d 63 3 noroxycodone.
This assay addresses an important aspect ...
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Bioanalytical Systems
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Purpose: A generic approach is presented that provides concrete, statistical
evidence for acceptable method performance prior to initiating a bioanalytical
method validation.
Methods: A large number of replicate spiked matrix samples are analyzed in a
single batch before a method validation is started. Careful selection of the
contents of this batch enables one to evaluate factors such as ...
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Bioanalytical Systems
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Ribavirin is an antiviral prodrug used for the treatment of Hepatitis C and respiratory syncytial virus (RSV) among other common viruses. A method for the analysis and quantification of ribavirin in rat plasma utilizing HPLC-MS/MS with updated HPLC column technology has been developed and validated according to the FDA guidance to the industry.
The assay displays good linearity with ...
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Bioanalytical Systems
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Introduction Amprenavir is a second generation human immunodeficiency viral protease inhibitor marketed as Agenerase by GlaxoWellcome under license from Vertex Pharmaceuticals. The drug has demonstrated both additive and synergistic pharmacological activity against HIV in combination therapies involving both protease and reverse transcriptase inhibitors. The goal of this work was to extend our ...
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Bioanalytical Systems
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Caffeine and its metabolites are ubiquitous in human biological fluids due to dietary consumption. The metabolites of caffeine are paraxanthine, theobromine and theophylline. The ratio of paraxanthine to caffeine may serve as a surrogate measurement of liver function, and thus, there is much interest in monitoring these two analytes simultaneously. Often times, the interference of theophylline to ...
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