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Blood Factors
Research Library
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Rules-Based Medicine
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Accurate measurement of immune activity in relation to therapeutic dosing is an important part of many clinical trials, yet is poorly addressed by traditional techniques. Typical immune activity monitoring is performed using isolated leukocytes or even sorted sub- population culturing methods followed by an analytical measurement. These methods require the shipment of intact blood samples to a ...
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ABC Laboratories
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Apomorphine (5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo [de,g]quinoline-10,11-diol) is a dopamine receptor agonist under development for the treatment of erectile dysfunction.The purpose of this study was to characterize the binding of apomorphine to plasma proteins from humans and various animal species (mouse, rat and dog) of each gender.The binding of apomorphine to plasma proteins was evaluated ...
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Covance
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In March 2006, six normal healthy volunteers par- ticipating in a clinical study in the UK were given an intravenous (IV) dose of an experimental immunother- apeutic as a part of an ascending single dose safety and tol- erability study. Within a few hours of drug administration, all subjects exhibited severe reactions which progressed to multiple organ failure. As a result of the incident, ...
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Cetero Research
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A crucial element in the development of topical and transdermal drug products is evaluation of the percutaneous absorption of the active pharmaceutical ingredient (API). Generally, the goal for topical products is to maximize cutaneous delivery of the API, whereas for transdermal products the goal is to achieve a specific rate of absorption sufficient to achieve a systemic blood level within the ...
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Archimedes, Inc.
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In 2002 some physicians at Kaiser Permanente came up with an idea: What if KP members
with diabetes or CAD were systematically given a bundle of drugs consisting of aspirin,
lovastatin (a cholesterol drug) and lisinopril (a blood pressure drug) – called “A-L-L”? Their
clinical intuition told them that it should have an important effect on complications, but there
was no direct evidence of ...
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