To date, transdermal delivery has been effective in delivering only a very few drugs due to difculties in moving larger, and chemically non-compatible, molecules across the skin's biologically-active barrier. Drugs with higher melting points, drugs of molecular weight greater than 500 Daltons and drugs requiring pharmacological doses of more than 40 mg in 24 hours can not employ patch- or ...
Boaz Mendzelevski, Director of Cardiology at Medifacts International, Inc. continues his investigation into cardiovascular safety in drug development, focusing on drug-induced vascular thrombosis and myocardial ischemia and infarction
Cardiac safety of new drugs in development has recently gained significant momentum due to increased regulatory and public attention. However, while the focus of ...
Testosterone, an endogenous hormone is the most important androgen secreted into the blood by the Leydig cells in the testes. In women, testosterone also is probably the prin- cipal androgen and is synthesized both in the corpus luteum and the adrenal cortex by simi- lar pathways [Snyder 2001]. Testosterone de- ficiency in men (hypogonadal) is always as- sociated with incomplete development of ...
With the worldwide rise of obesity and metabolic diseases, labs should conduct ongoing test monitoring to see what may be of value for obesity. This report covers which tests are well-established and which provide beneficial results.
DOI:10.1111/j.1365-2125.2005.02542.x British Journal of Clinical Pharmacology
Pharmacokinetics of a new testosterone transdermal
delivery system, TDS®-testosterone in healthy males
Z. Chik,1 A. Johnston,1 A. T. Tucker,1,2 S. L. Chew,3 L. Michaels4 & C. A. S. Alam5 1Clinical Pharmacology, 5Experimental Pathology, 3Endocrinology, William Harvey Research Institute, Barts and The London, Queen ...
It is well-known that certain cancer cells have a hormone dependence and that earlier diagnosis and treatment of hormonally driven cancers can be based on the chemical profile of a tumor. Estrogens and their metabolites are suspected in the development and growth of certain types of breast cancer. Current analytical methodology limits screening of samples due to the extended analytical times ...
To develop and validate an LC-MS/MS method for the determination of cortisol in human saliva containing 1.5 mM citric acid. Among other functions, cortisol serves to help the body manage stress and has been termed “the stress hormone” because it is also secreted in higher levels during the body’s response to stress. Therefore, the levels of cortisol can be used as a biomarker and pharmacodynamic ...
A specific and sensitive HPLC-MS/MS method was developed and validated for the quantitation of PT-141 for a linear range of 0.500-100 ng/mL in human plasma and 5.00-2500 ng/mL in rat plasma.
PT-141 is an analog of α-melanocyte-stimulating hormone (α -MSH) with agonist activity at the melanocortin receptor (MCR) subtypes 1, 3, 4, & 5. Melanocortin peptides have been implicated in several ...
A sensitive radioimmunoassay (RIA) method was validated for the determination of octreotide in male rat plasma using reagents provided in the kits by Peninsula Laboratories, Inc. (Belmont, CA). The components provided in the RIA kit were used to validate octreotide in male rat plasma over a concentration range of 80-1280 pg/mL.
Octreotide mimics the action of somatostatin, a naturally ...
In the lucrative business environment of horse breeding there are time and cost pressures to improve the tools currently used to predict ovulation and streamline the breeding process. The standard methods of determining optimum breeding time in horses include daily transrectal ultrasonography to follow and measure a dominant follicle during estrous as well as progesterone assays as an indicator ...
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