Chemical Ingredients

View All Whitepapers
EMD Chemicals Inc.	Non-Steroroidal Cyclooxygenase (COX) Inhibitors Cyclooxygenases (COXs), also known as prostaglandin H synthases, are fatty acid oxygenases that contain about 600 amino acid residues and act on arachidonic acid to generate prostaglandins (PG). All vertebrates contain two COX genes: one encoding the constitutive COX-1 and another inducible COX-2. COX-1 and COX-2 share approximately 60-65% amino acid identity. These COX isoforms are bifunctional ...
EMD Chemicals Inc.	p53 and MDM2: Partners in Repair and Death In unstressed cells, p53 is latent and is maintained at low levels by targeted degradation mediated by MDM2. Through its binding to p53, MDM2 can shuttle p53 out of the nucleus into the cytoplasm for degradation. When normal mammalian cells are subjected to stress signals, such as hypoxia, radiation, and chemotherapeutic drugs, p53 is phosphorylated at multiple sites, including those involved in ...
EMD Chemicals Inc.	Telomere, Telomerase, and Cellular Senescence and Death Telomerase is a specialized ribonucleoprotein composed of telomerase reverse transcriptase (TERT), an intrinsic RNA template (TR), and several associated proteins. Its main function is to stabilize telomeres, which protect chromosomes from recombination and end-to-end fusion. Telomeres also recognize DNA damage and control the replicative capability of cells. With each cell division some of ...
EMD Chemicals Inc.	TGF-B Signalling: Dual Role in Tumor Suppression and Oncogenisis Transforming growth factor- (TGF-), a member of the TGF superfamily of proteins that includes activins, inhibins, and bone morphogenetic proteins (BMPs), regulates a wide array of cellular processes including cell differentiation, cellular senescence, immune response, wound healing, and apoptosis. TGF- signaling promotes growth and development during early embryogenesis. However, in mature ...
Sigma-Aldrich Co.	Screening and Profiling Protein Expression in Human Cancer Serum using Antibody ... There is a growing need for technologies that enable discovery and validation of protein biomarkers in human serum/plasma. Antibody microarrays have been used successfully to rapidly identify and characterize protein expression in a targeted approach. In this study, antibody arrays were used to interrogate proteome differences in whole serum and in serum that had been depleted of twenty high ...
View All Whitepapers

Chemical Ingredients Research Library