Drug Delivery

Drug Delivery Research Library

Contract Manufacturing in Puerto Rico
Patheon Inc.
In an era characterized by the need to continuously evaluate and bolster R&D pipelines, the increasing complexity and overall cost to develop and approve drug products, the trend toward genericization, and mounting pressures to both decrease prices and maximize profitability, the pharmaceutical industry has sought competitive advantage in lower cost manufacturing jurisdictions. The ...
 
Telomere, Telomerase, and Cellular Senescence and Death
EMD Chemicals Inc.
Telomerase is a specialized ribonucleoprotein composed of telomerase reverse transcriptase (TERT), an intrinsic RNA template (TR), and several associated proteins. Its main function is to stabilize telomeres, which protect chromosomes from recombination and end-to-end fusion. Telomeres also recognize DNA damage and control the replicative capability of cells. With each cell division some of ...
 
Hepatobiliary Disposition
Hamilton Robotics
Prediction of the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of compounds in pharmaceutical development are essential aspects of the drug discovery process. B-CLEAR® (sandwich-cultured hepatocytes) is an in vitro system that is used to analyze and predict the in vivo hepatobiliary disposition (hepatic uptake, biliary excretion, and biliary clearance) and ...
 
p53 and MDM2: Partners in Repair and Death
EMD Chemicals Inc.
In unstressed cells, p53 is latent and is maintained at low levels by targeted degradation mediated by MDM2. Through its binding to p53, MDM2 can shuttle p53 out of the nucleus into the cytoplasm for degradation. When normal mammalian cells are subjected to stress signals, such as hypoxia, radiation, and chemotherapeutic drugs, p53 is phosphorylated at multiple sites, including those involved in ...
 
TGF-B Signalling: Dual Role in Tumor Suppression and Oncogenisis
EMD Chemicals Inc.
Transforming growth factor- (TGF-), a member of the TGF superfamily of proteins that includes activins, inhibins, and bone morphogenetic proteins (BMPs), regulates a wide array of cellular processes including cell differentiation, cellular senescence, immune response, wound healing, and apoptosis. TGF- signaling promotes growth and development during early embryogenesis. However, in mature ...
 

Drug Delivery Video

Nimbus Hamilton Robotics The MICROLAB® NIMBUS is Hamilton Company's newest automated multi-channel pipetting platform, offering a high density deck layout in a body small enough ...
 
Nano Pipettor Hamilton Robotics Video on the Nanopipettor: 100 nl dispens on the fly raster: 1536
 
Drug Delivery EMD Chemicals Inc. Products

PharmaTech Features

Drug Delivery Microfluidics Products
Drug Delivery Woodley Equipment Company Ltd Products
Drug Delivery Patheon Inc. Information
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