Drug Discovery
Research Library
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EMD Chemicals Inc.
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In unstressed cells, p53 is latent and is maintained at low levels by targeted degradation mediated by MDM2. Through its binding to p53, MDM2 can shuttle p53 out of the nucleus into the cytoplasm for degradation. When normal mammalian cells are subjected to stress signals, such as hypoxia, radiation, and chemotherapeutic drugs, p53 is phosphorylated at multiple sites, including those involved in ...
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BioClinica, Inc.
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Global clinical trial solutions. Real-world results.
The Case for Functional Outsourcing of EDC
The Business Case for Functional Outsourcing of EDC
Summary: This white paper is intended for clinical operations managers who are either considering their electronic data capture (EDC) options for the first time or re-evaluating previous decisions. This paper looks at the primary approaches for ...
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Covance
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The approval by the Food and Drug Administration (FDA) of the first inhaled insulin combination product for treatment of diabetes represents a milestone in drug delivery. Exubera is an inhaled powder form of recombinant human insulin (rDNA) used in the treatment of adult patients with type 1 and type 2 diabetes and is the first new delivery option introduced since the discovery of insulin in the ...
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BIOCIUS Life Sciences (formerly BioTrove RapidFire)
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Cytochrome P450s (CYP450) mediate the biotransformation of drug compounds. Metabolism of multiple test compounds by the same CYP450 isoform can alter reaction kinetics and result in adverse drug-drug interactions (DDI). Therefore, high throughput-DDI assays are valuable tools in the go/no-go decision-making process in drug discovery. Mass spectrometry-based CYP450 assays have emerged as the ...
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TranSenda International
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Leverage the Microsoft Office System to conduct clinical trials like never before - now each person can have their own view of all the latest information in a controlled environment, combining your investment in applications and the knowledge of your staff.
The Microsoft Office system is comprised of the familar Microsoft Office applications. Microsoft Word, Excel, PowerPoint and Outlook are ...
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