Blood Plasma - Fractionation

Blood Plasma - Fractionation

GEA Diessel supplies process technologies for the processing of blood plasma; fractionation, concentration, pre- and post-virus inactivation, purification, buffer production, storage & distribution.

Whatever it is you need your process plant for: the fractionation and manufacture of products from immunoglobulins, human albumins, Factor VIII, Factor IX or whatever – our wide range of plant concepts will provide the equipment you need to meet any requirements or conditions. By using the most advanced manufacturing concepts for vessels and skids and the latest components and valve technology, we ensure that your plant manufactures your products economically and in a way that’s kind to the source materials too.

As a competent manufacturer of complete plant for the pharmaceutical industry, GEA Diessel offers you a full service to meet every specification. From the planning, development and installation of your new process plant all the way to qualification and maintenance – our experienced engineers will work with your project team to develop innovative and efficient process technologies for your very individual blood plasma processing applications.

From blood plasma to medication - all process technologies from one source
The manufacture of pharmaceutical products from blood plasma by plasma fractionation requires process conditions that are extremely kind to the product. These products are manufactured under sterile conditions that require materials and processing of the highest quality. In addition, the process has to comply with a large number of national and international standards and statutory provisions.

Manufacturers, therefore, expect great precision in the manufacture and assembly of their process plant. Every detail of the design must comply with high quality standards to avoid production errors. Using high-performance processing equipment helps guarantee reliable production.

Technologies used:

centrifugation and filtration for solid/liquid separation
thermal and chemical inactivation procedure
ultrafiltration/diafiltration
nanofiltration
chromatography

Essential process requirements:

gentle thawing of the plasma through precise temperature control and regulated stirring
appropriate conditions for solid/liquid separation by centrifugation or filtration to separate the plasma fractions
special filtration techniques to gain eluate for the manufacture of Factor IX
exact temperature control for the precipitation of all fractions
design free of dead-leg areas
compliance with emission regulations when dosing the precipitation medium

Everything automated
GEA Diessel provides for all important parameters to be monitored by a high-performance control system, with all processes being visualised. The control system automatically administers all parameters and records and documents all data, steps and parameters that are important to the process.

CIP / SIP
An essential part of a high-quality production of blood plasma is an integrated CIP/SIP system. GEA Diessel provides efficient cleaning and sterilisation processes to meet your individual demands and to ensure the correct cleaning media is delivered to the right place at the right time. We have a large range of cleaning options from mobile, independent cleaning systems up to diverse CIP satellites fed with conditioned cleaning solutions.

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