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Greenville, North Carolina 27834
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252-752-3800
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Sales - General Tom Salus
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Formulation Management Research Library

Using Quality by Design (QbD) for Process Optimization of a Novel Oral Solid Dosage Form
Metrics Contract Services
Joe Cobb and his team used the principles of QbD to improve the robustness of a core tablet for a novel modified release oral solid dosage form. View the AAPS 2012 poster and watch a short video about how Metrics applies the principles of QbD to solve formulation development issues.
 
Dissolution of a Phosphate Prodrug from  Hard Gelatin Capsules: A Case Study
Metrics Contract Services
Dissolution of a Phosphate Prodrug from Hard Gelatin Capsules: A Case Study Thomas B. Gold, Jennifer G. Warren, and David R. Collier OBJECTIVE To compare dissolution of a phosphate prodrug from three capsule shell types. BACKGROUND Clinical studies often include an active comparator (an active control) in the specific study design. The respective design compares the standard therapy ...
 
Detection of Label Photoinitiator in a Potent Product: A Case Study
Metrics Contract Services
Detection of Label Photoinitiator in a Potent Product: A Case Study D. Williamson, M. Ruff, K. Rispress, J. Warren, F. Harrington OBJECTIVE To describe the detection and identification of a benzophenone, used as a bottle label photoinitiator, encountered during routine stability monitoring of a potent drug product utilizing a sensitive analytical method. BACKGROUND An unidentified peak (UNID) ...
 
Increase of Drug Load and Potency of a  Capsule Formulation by Conversion from a  Simple Powder Blend to Roller Compaction
Metrics Contract Services
Increase of Drug Load and Potency of a \nCapsule Formulation by Conversion from a \nSimple Powder Blend to Roller Compaction\n\nOBJECTIVE\nTo increase drug load and potency in a powder encapsulation formulation by conversion of a simple powder blend process to one including dry granulation by roller compaction.\n\nGeneral Background\nMany times in early phase drug product development the desired ...
 

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