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Pharmaceuticals Research Library

Quantitative Analysis of IGF-1 Using Online Digestion Coupled to the Triple Quad LCMS-8050
Shimadzu
IGF-1 is a protein used in the screening of growth hormone deficiencies, as well as testing for abuse in professional sports. Detection using an LC-MS approach is emerging as a preferred test to the standard immunoassay due to the improved reproducibility that LC-MS offers as well as the ability to multiplex and identify biologically relevant changes such as post translational modifications.
 
Determination of Heroin Hapten Densities in Protein Conjugates: Comparison of MALDI-TOF MS, TNBS and Indirect Ellman Assay
Shimadzu
Presenting a comparison of MALDI-TOF high molecular weight measurement accuracy in predicting drug conjugates densities versus two established colorimetric techniques: trinitrobenezenesulfonic acid (TNBS) and Indirect Ellman assay. The study makes a strong case for MALDI-TOF as a tool of choice for protein-drug conjugates analysis.
 
HPLC Analysis of Impurities in New-generation Antidepressants
Shimadzu
Presented in this note is an example of analysis of compounds related to new-generation antidepressants, as well as system suitability testing, using the Prominence-i integrated HPLC, which features a delay volume-compatible system kit option.
 
Rapid and Reproducible Analysis of Peptides using the Triple Quad LCMS-8050
Shimadzu
Recent innovations with Skyline have resulted in a version of Skyline that can upload and analyze *.lcd files directly. We applied this analysis to demonstrate the integration of Shimadzu products into the Skyline environment. Using this workflow, we identified CVs of less than 2 % for several experimental approaches.
 
Investigation of Synthetic Compounds in Drug Discovery by Integrated HPLC and LC/MS
Shimadzu
This paper introduces an analysis of eight pharmaceutical substances in a workflow that is typically used for pharmaceutical synthesis confirmation analysis. It describes an example in which measurement was conducted for a range of compounds with properties spanning acidic to basic, and high to low polarity.
 

Pharmaceuticals Marketing Documents

High-Speed Liquid Chromatograph Mass Spectrometer
 
Cookie Cutter Proteolysis: Achieving Reproducible, Efficient Digestions for Proteomic Workflows
 
Mechanical Strength Evaluation of Functional Film Used in Smartphones
 
Determination of Drugs in Serum using Heart-cutting Two-dimensional Ultra High Performance Liquid Chromatography
 

Pharmaceuticals Video

Nexera UHPLC - Full Version Shimadzu Laboratory applications for LC systems are very diverse, extending from the product development phase to verification of quality. Therefore, a modular ...
 
Tracera - Plasma Technology is the Future of GC Dectection Shimadzu The new Tracera GC System is now ready to solve your trace analysis needs. This system utilizes the new Barrier Discharge Ionization Detector technology ...
 
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