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Monoclonal Antibody Production

    
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Biomatik  Biomatik provides one stop source for bio-reagents, ELISA kits, custom gene synthesis, peptide synthesis, custom antibody and protein production services.
 
Anti-beta-Actin Loading Control Monoclonal Antibody, Mouse Anti-beta-Actin Loading Control Monoclonal Antibody, Mouse
 
Anti-HA Tag Monoclonal Antibody, Mouse Anti-HA Tag Monoclonal Antibody, Mouse
 
BioVectra Inc.   Contract Manufacturing Organization (CMO). GMP Fermentation and chemical synthesis of API's, PEGylation reagents, highly potent compounds. Reducing and oxidizing reagents for protein chemistry.
 
VectraCell™ Single-Use Bioreactors
EMD Millipore Bioscience  The Bioscience portfolio delivers products & services for life science research in academic & pharmaceutical environments. Our focus on genomic, proteomic & cellular analysis is supported by sample preparation, research...
 
Anti- IL-27 beta, clone EPR5747, Rabbit Monoclonal Antibody Interleukin-27 subunit beta (IL-27 subunit beta or IL-27B or IL-27 beta), also known as Epstein-Barr virus-induced gene 3 protein (EBV-induced gene 3...
 
Anti- STING, clone 41 STING, also known as mSTING, or Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, MMITA or Transmembrane protein 173, and...
 
Maine Biotechnology Services  Maine Biotechnology Services provides custom monoclonal antibody development, polyclonal antibody development, matched pair analysis, bulk antibody production, antibody purification services, and assay development...
 
Antibody Production Services- Maine Biotechnology Services Maine Biotechnology Services offers both in vivo and in vitro antibody production in our cGMP facility at pilot and bulk scales. In Vivo Monoclonal...
 
Anti-Idiotypic / Neutralizing Antibody Development Often our customers develop anti-idiotypic antibodies as controls for antibody neutralization assays. Anti-Id antibody candidates are screened for the...
 
United States Biological  USBiological is a long-established biotech manufacturer located near Boston, offering a wide range of biologicals, biochemicals and the largest selection of antibodies you will find anywhere. USBio offers over 400,000...
 
Antibodies for Infectious Diseases Infectious diseases, both human and animal, are an ongoing problem throughout the world. United States Biological carries a variety of both monoclonal and...
 
Custom Services: Peptides Custom Peptide Synthesis
ProSci Incorporated  Antibody Supplier: Affinity-purified antibody, peptide-specific polyclonal antibodies to novel antigens, monoclonal antibody production, polyclonal antibody production, lysates, immunoblots, recombinant proteins
 
ACRP30 / Adiponectin (MAb Ne.Na) Antibody Adiponectin (monoclonal Ne.Na) antibody was raised against recombinant human ACRP30headless (tail adiponectin). Does not cross-react with full length...
 
Apaf-1 Monoclonal Antibody Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain...
 
Open Monoclonal Technology  OMT is a private biotechnology company developing a new, fully human monoclonal antibody (mAb) platform based on transgenic rats. The rat is a widely used laboratory animal with a well characterized immune system, a...
 
OMT'S Antibody Platform Monoclonal antibodies (mAbs) have been the primary focus of drug-development efforts since the early 1990s. Many pharmaceutical companies have entered the...
Capra Science Antibodies AB  Capra Science provides custom antibody services; poly- and monoclonal antibody generation and production, peptide-specific antibodies, purifications, humanization of antibodies and assay development.
SDIX  antibody development, antibody production, monoclonal antibody, polyclonal antibodies, critical reagents, assay development, immunoassay development, antigen design, genomic antibody technology, GAT, genomic antibodies,...
 
In-Vitro Production Monoclonal antibody is produced in vitro using roller bottles. Production in roller bottles allows precise definition of the proteins and other molecules...
 
Large Scale Production To provide maximum antibody yield during production, SDIX examines the viability of your cell line and the clonality of your cell line. Clonality is the...
Randox Life Sciences  Randox Life Sciences is a recognised primary manufacturer of high quality and cost-effective human recombinant proteins, polyclonal and monoclonal antibodies providing custom antibody production.
Agrisera  Agrisera is a Swedish company specialized in polyclonal and monoclonal antibody production with almost 30 years of experience. We take pride in our high service level and our antibodies that really work. Based on our...
 
Monoclonal antibodies Each of the listed services from Phase I to Phase III can be offered separately. Time schedule - approximately 4-8 months depending upon the immunogenic...
Acorda Therapeutics Inc.  Acorda Therapeutics is a biotechnology company whose mission is to develop and market therapies to restore neurological function in people with spinal cord injury (SCI), multiple sclerosis (MS) and related conditions of...
NewEast Biosciences  Monoclonal Antibodies for Active GTPases ( Ras, Ran, Cdc42, RhoA, RAC, Gao, Gaz, Gas, Gai and Ga13)
 
anti-ß1-Adrenergic Receptor Mouse Monoclonal Antibody Turkey ß1-adrenergic receptor (ß1-AR) belongs to the super-family of G protein-coupled receptors. ß-Adrenergic receptors can activate G protein Gs, leading...
 
Anti-Active Cdc42-GTP Mouse Monoclonal Antibody Only recognizes GTP-bound Cdc42 (CDC42-GTP).
 
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Monoclonal Antibody Production - Product Reviews

Creative Biomart – Diagnostic antibodies and recombinant proteins
Jeff Kelly, Online Industry Editor

With more than 3,000 diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes, and recombinant proteins on offer, Creative Biomart is one of the largest suppliers to the clinical research, molecular diagnostics and biopharmaceutical drug development industries.

Read full product review


Monoclonal antibody therapy has entered a new arena: treatment of diarrhea.

Monoclonal antibodies, which are extensively used in fundamental research, medicine and biotechnology, may be the answer to a growing problem in the area of in-patient care: life-threatening diarrhea.  There is a dark side to the increasing use of antibiotics: the intestinal diseases which come about when normal gut bacteria are eliminated by these antibiotics, enabling infection by Clostridium difficile. Patients who spend only two days in hospital have a 10% chance of infection, which rises to 50% with stays of over a month. In 2007, there were 33.6 deaths per 100,000 discharged patients, representing a 147% increase in 11 years. Some patients are at higher risk because there is a 60% chance of reoccurrence in patients who have had more than one episode of infection.

Donna Ambrosino, MD, from MassBiologics reports that “We need new approaches to prevent the recurrence of C. difficile to decrease morbidity, hospitalizations and health utilization costs.” Monoclonal antibodies appear to provide this new approach. There was an astonishing 70% reduction in the recurrence rate of infection in a recent study involving adding monoclonal antibodies to the standard of care antibiotics therapy.

Best-in-Class Monoclonal Antibody Producers Feature:

  • Full-service monoclonal antibody production services from hybridoma development to monoclonal antibody development, production, purification and post processing.
  • Design metrics capable of integrating all aspects of monoclonal antibody development, from initial research to manufacture.
  • High yield assay techniques such as enzyme-linked immunosorbent assay (ELISA), antigen microarray assay or immuno-dot blot assay method.

Top Considerations before Buying Monoclonal Antibodies:

One of the most important things to look for when choosing a provider is whether they have an effective integration scheme. This will result in shorter product development time, getting you to the therapeutic lead stage sooner, which is always a key consideration in emerging biotech markets.

Key Producers:
 
1. AMS Biotechnology (Europe) Ltd (amsbio) provides life science research reagents and services to small and medium-sized manufacturers. Its expanding catalogue contains 285,000 products. amsbio, which was founded in 1987 and restructured in 1997, specializes in Genomics, Proteomics and Immunology. This ISO 9001:2008 registered company added monoclonal antibody production to its peptide and polyclonal antibody services in 2004. Future plans include adding DNA damage screening, Cell Assays, Tumour Xenograft, and primate and rodent services. ambios is able to ship products to companies around the world from its offices in Switzerland, Germany and the UK.

2. Maine Biotechnology Services (MBS) offers complete antibody services, including hybridoma development, polyclonal antibody development, antibody production, purification and post processing. Its MultiPure technology enables customers to assess relative affinity, physical characteristics and matched pair capability before proceeding to subcloning. What sets it apart is its Academic Discovery Track, a scaled-down antibody development which is an affordable alternative for researchers and academics. MBS is continually expanding its product line and services. Recent additions include two antibodies that recognize large, small and branched versions of Polyethylene glycol (PEG). This Portland, Maine-based company, founded in 1990, ships products to companies around the United States and in the European Union.

3. Thermo Fisher Scientific was created in 2006 when Thermo Electron, founded in 1956 to provide analytical and laboratory products and services, and Fisher Scientific, founded in 1902 to provide laboratory equipment, chemicals, supplies and services, joined forces. This synergy allowed Thermo Fisher to become a global company with offices and operations around the world. The Fisher Scientific division offers a complete portfolio of laboratory equipment, chemicals, supplies and services. Thermo Scientific produces analytical instruments, laboratory equipment, software, consumables and reagents and provides a range of services including ways to improve workflow from sample preparation and sample analysis to data interpretation.

4. Acorda Therapeutics' core business is the development of therapies that will help restore nerve function to patients who have experienced damage to the spinal cord (SCI) or are afflicted by multiple sclerosis (MS) or other disorders of the nervous system. Acorda has three preclinical programs focused on finding new approaches to the repair of the central nervous system (CNS). The first involves testing the use of Chondriotinase to break down the scar tissue that develops as a result of spinal injury. The other two concern stimulating repair of the myelin sheath with either remyelinating antibodies or neuregulin growth factors. Acorda was founded in 1995 and is based in Hawthorne, NY,

Monoclonal antibodies
Definition: Monoclonal antibodies are made from a single immune cell clone or cell line and are therefore identical. "Immortalised" hybridoma cells, which are hybrids of an antibody-producing mortal lymphoid cell and a malignant (immortal) myeloma cell, are able to continuously secrete these specific antibodies, in theory providing an unlimited supply. Monoclonal antibodies can be synthesized to specifically bind to almost any substance, enabling either purification of that substance or detection of trace amounts in a heterogeneous substance.

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Monoclonal Antibody Production Research Library

Progesterone Antibody White Paper
Maine Biotechnology Services
Maine Biotechnology Services Your Partner in Antibody Development MAB234P and MAB235P, monoclonal antibodies to progesterone, are now ready for sampling. The most accurate formats for measurement of progesterone in clinical samples are competition and/or inhibition assays since the molecule is only 314 daltons. Progesterone in a clinical sample competes with a carefully chosen conjugated ...
 
Bioprocessing and Partnering
Laureate Biopharma
Robert J Broeze is the President and Chief Executive Officer of Laureate Pharma. He has over 20 years of experience in the biopharmaceutical industry, with technical expertise spanning research, development, characterisation, validation and current Good Manufacturing Process (cGMP) manufacture of biopharmaceutical products, from pilot to phase III clinical and commercial scale with a strong ...
 
ProMab Biotechnologies, Inc Custom mAb Production
ProMab Biotechnologies, Inc
Immunization and boosts of 5 Balb/c mice with standard immunization protocol. ELISA evaluation of titer prior to selection for fusion. Approximately 3-4 mg protein immunogen or 2 mg conjugated peptide immunogen and 0.5 mg free peptide are required. $800 due at the beginning of phase Estimated time: 8 weeks Once an acceptable titer is obtained, hybridoma fusion will be done using splenocytes from ...
 
Myeloperoxidase Antibodies
Maine Biotechnology Services
MAB208P and MAB209P Recognize native human myeloperoxidase Antibodies work as a matched pair in a sandwich ELISA Do not cross-react with human lactoferrin or bovine lactoperoxidase Outperform current gold standard in flow cytometry applications Lymphocytes = Low MPO levels Monocytes = Intermediate MPO levels Granulocytes = High MPO levels (Figure A) ELISA using MAB208P as the capture antibody ...
 
A Guide to the Different Techniques in Which Antibodies are Used
Randox Life Sciences
A guide to the different techniques in which antibodies are used Enzyme Linked Immunosorbent Assay or ELISA is one of the most common tests conducted in immunobiochemistry. The principle involves immobilising antibodies onto a microtitre plate. These antibodies are labelled with an enzyme; the fixed enzyme reacts with the substrate to yield a coloured product allowing the qualification and ...
 

Monoclonal Antibody Production Video

EMD Millipore Overview EMD Millipore Bioscience EMD Millipore is a leading supplier in the life sciences industry with over 60,000 products, tools and technologies on the market. We provide ...
 
RayBiotech Product Overview.wmv RayBiotech, Inc.
 
Monoclonal Antibody Production EMD Millipore Bioscience Information

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Monoclonal Antibody Production BioVectra Inc. Information
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