Dow Wolff Cellulosics Dow Wolff Cellulosics is the preferred development partner and premier application expert in the fields we cover, catering to the changing needs of all formulators and brand owners whose label claims are enabled by Dow...
BASF Fine Chemicals Switzerland SA BASF offers pharmaceutical companies a wide variety of excipients for making successful drugs from active ingredients with tremendous potential. In this way, the product spectrum fulfils all functional and regulatory...
In vitro:in vivo Correlation: Topical Delivery Review of the literature of the past 40+ years reveals the great extent to which our understanding of the fun- damentals of percutaneous absorption depends upon a simple, yet multifaceted, model system: the in vitro use of excised animal or human skin mounted as a barrier be- tween two glass chambers. For those who believe that data obtained in vitro ...
Crystal engineering provides a rational approach to solving formulation, processing and product performance problems. This review discusses how the concept of crystal engineering can be judiciously utilized to manipulate the solid-state properties of
drugs and excipients for successful pharmaceutical formulation and process development.
Existing and emerging manufacturing as well as ...
We believe that the main reason for the apparent fall in productivity with increasing scale is the concomitant increase in organizational complexity. It is our premise that breaking Big Pharma into entities of more manageable scale will assist them in increasing R&D productivity. Horizontal disintegration (where end-to-end processes in the value chain are kept together, but the scopes of these ...
The formulation of drugs into capsules is often utilized in early phase development due to the relatively quicker formulation-development process. The bioavailability of the poorly soluble drugs can be significantly increased when formulated in a solubilized form in a capsule (i.e. liquid or semi-solid filled capsules). Acidic degradation and dyspeptic side effects associated with some compounds ...
The purpose of this paper is to discuss the application of Raman spectroscopy to the unique requirements of raw material testing. In order to do so we will answer the following questions: 1. What is and why perform identity testing? 2. What are the incentives to speed up testing? 3. Should we consider modifying the testing process? 4. How does the TruScan handheld Raman instrument perform ID ...
Dissolution is an important test method that is carried out on solid oral dosage forms like capsules, tablets, and oral suspensions. For these dosage forms to be efficacious, the active drug substance must be absorbed into the systemic circulation so that it can be transported to its site of activity. The overall efficiency of this process contributes to the bioavailability of the drug substance ...
The purpose of this paper is to discuss the application of Raman spectroscopy to the unique requirements of raw material testing. In order to do so we will answer the following questions: 1. What is and why perform identity testing? 2. What are the incentives to speed up testing? 3. Should we consider modifying the testing process? 4. How does the TruScan handheld Raman instrument perform ID ...
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