What is an antibody? An antibody is an immunoglobulin protein, secreted by B lymphocytes, that is present in serum or body fluid and combines specifically with an antigen. Antigens are classically defined as any foreign substance that elicits an immune response. An antigen that produces an adaptive immune response after injection into an animal is an immunogen. Immunogens can be designed so that ...
Crystal engineering provides a rational approach to solving formulation, processing and product performance problems. This review discusses how the concept of crystal engineering can be judiciously utilized to manipulate the solid-state properties of
drugs and excipients for successful pharmaceutical formulation and process development.
Existing and emerging manufacturing as well as ...
Effcient, nonselective methods to obtain DNA from the environment are needed for rapid and thorough analysis of introduced microorganisms in environmental samples and for analysis of microbial community diversity in soil. A small-scale procedure to rapidly extract and purify DNA from soils was developed for in-the-eld use. Amounts of DNA released from bacterial vegetative cells, bacterial ...
This article describes an investigation into why gelatin capsule
shells filled with hygroscopic materials sometimes crack. Its conclusions counter important aspects of the traditional theory.
As the popularity of liquid-filled hard capsules (LFHCs)
increases, formulators are becoming more interested in
ways to evaluate the compatibility of their formulations
with the capsule shell, ...
Capsules are incompatible with some fills. For instance, some for- mulations cause them to dissolve—almost seeming to melt—while others cause cracks to spontaneously form. While both effects stem A from an interaction between the fill and the capsule shell, crack formation requires the additional presence of mechanical stress on the shell. This article describes an investigation into how areas of ...
Common literature methods for determining formalde- hyde in air and water are based on derivatizing formalde- hyde first, by the use of either 2,4-dinitrophenylhydrazine (DNPH) or 2,3,4,5,6-pentafluorobenzyloxyamine (PFBOA) and then quantitating the resulting hydrazone or oxime. We report general procedures for the derivatization and determination of total extractable formaldehyde as well as ...
How to Guide for Writing a Drug Master File Introduction A drug master file (DMF) is a proprietary document typically written by or for the manufacturer to protect manufacturing information, an intermediate, starting raw material, Active Pharmaceutical Ingredient (API), description of production site/s or for other special requests. Most often, DMF's are written to protect the manufacturing ...
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