Biochem Tek(Shanghai) Co,ltd Biochemtek is a research and development company focused on the discovery of new moleculars.
We provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds and...
Echelon Biosciences Inc. Echelon was organized to further the science of lipid cell signaling and critical metabolic enzymes, which provide new and viable targets for the development of potential drugs and diagnostics for cancer, diabetes,...
United States Biological USBiological is a long-established biotech manufacturer located near Boston, offering a wide range of biologicals, biochemicals and the largest selection of antibodies you will find anywhere. USBio offers over 100,000...
Talecris Biotherapeutics Talecris is proudly building upon a 60-year legacy of innovation and a commitment to improving the lives of people who rely on its therapeutic products.Talecris Biotherapeutics is a global biotherapeutic and biotechnology...
Prolastin, Alpha1-Proteinase Inhibitor (Human)
Alpha1-antitrypsin (AAT) deficiency, also known as Alpha-1, is a genetic (inherited) disorder that causes significant reduction in the naturally occurring...
Arena Pharmaceuticals, Inc. Arena is a clinical-stage biopharmaceutical company committed to discovering and developing innovative therapies offering significant medical advances and new options for patients. We are focused on discovering,...
APD916 for Narcolepsy and Cataplexy
APD916, our lead drug candidate for narcolepsy and cataplexy, is a potent and selective inhibitor of the histamine H3 receptor. The histamine H3 receptor is...
amsbio AMS Biotechnology, Leader in developing modern products and technologies for life science research: Antibody, Protein, Peptide, Apoptosis, Migration, Cell Proliferation kits and reagents, Cytokines, Protein Kinases,...
Purpose: To characterize the cytochrome 450 (CYP450) isoenzymes involved in the metabolism of brinzolamide by human liver microsomes using 1) Correlation analysis with typed human liver microsomes from individual livers, and 2) Inhibition with CYP450 isoenzyme-selective chemical inhibitors.
An LC-MS/MS method was developed for the quantitation of N-desethyl brinzolamide, O-desmethyl ...
Nolatrexed dihydrochloride, a thymidylate synthase inhibitor, is a novel oncology compound that is being developed to treat several different cancers, with an initial emphasis in hepatocellular carcinoma (liver cancer). Nolatrexed dihydrochloride is currently in a Phase III trial for the treatment of unresectable hepatocellular carcinoma.
A sensitive and specific HPLC-UV method was developed ...
Over the past number of years HIV medication development mainly focused on treatment simplification with the development of fixed dose combination tablets. However, during the last two years, significant progress was made to increase the number of new compounds available to patients; not only did the FDA approve a new protease inhibitor (duranavir, 2006) and a NNRTI (Etravirine, 2008), there was ...
Rapamycin, also known as Sirolimus, was discovered in 1965, when it was isolated from a microorganism in soil. Since its discovery, it has demonstrated useful immunosuppressive properties, which have been utilized in preventing the rejection of organ transplants. Rapamycin is a mTOR inhibitor that has an advantage over calcineurin inhibitors, such as tacrolimus and cyclosporine, since it is not ...
Introduction Amprenavir is a second generation human immunodeficiency viral protease inhibitor marketed as Agenerase by GlaxoWellcome under license from Vertex Pharmaceuticals. The drug has demonstrated both additive and synergistic pharmacological activity against HIV in combination therapies involving both protease and reverse transcriptase inhibitors. The goal of this work was to extend our ...
Cyclooxygenases (COXs), also known as prostaglandin H synthases, are fatty acid oxygenases that contain about 600 amino acid residues and act on arachidonic acid to generate prostaglandins (PG). All vertebrates contain two COX genes: one encoding the constitutive COX-1 and another inducible COX-2. COX-1 and COX-2 share approximately 60-65% amino acid identity. These COX isoforms are bifunctional ...
High-throughput and virtual screening are widely used to discover novel leads for drug design. On examination, many screening hits appear non-drug-like: they act noncompetitively, show little relationship between structure and activity, and have poor selectivity. Attempts to develop these peculiar molecules into viable leads are often futile, and much time can be wasted on the characterization of ...
Enoximone is a selective PDE-3 inhibitor currently in Phase III development for the treatment of advanced chronic heart failure. Enoximone is metabolized to the primary metabolite, enantiomeric enoximone sulfoxide, and it is important to determine if this conversion is stereoselective.
Erythromycin is a known CYP3A4 inhibitor and is used in the investigation of potential drug-drug interactions in clinical studies.1 A specific HPLC-MS/MS assay method for the determination of erythromycin in human plasma was developed and validated according to the current industry guidelines.
Erythromycin is a known CYP3A4 inhibitor and is used in the investigation of potential drug-drug interactions in clinical studies.1 A specific HPLC-MS/MS assay method for the determination of erythromycin in human plasma was developed and validated according to the current industry guidelines.2
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