Lyne Laboratories Lyne has been providing contract manufacturing services to large and mid-size ethical pharmaceutical companies, small biotech start-ups, and virtual companies for more than 30 years. We specialize in the manufacture of...
Novo Nordisk The headquarters for our North American business, supports approximately 4,000 employees nationwide handling sales, marketing, managed care, trade and government, research and manufacturing activities. Other departments...
GEA Pharma Systems Supplies of advanced processing equipment for the manufacturing of oral and parenteral dosage forms - Granulation and Drying, Materials Handling, Tablet Compression and Lyophilization.
Transforming growth factor- (TGF-), a member of the TGF superfamily of proteins that includes activins, inhibins, and bone morphogenetic proteins (BMPs), regulates a wide array of cellular processes including cell differentiation, cellular senescence, immune response, wound healing, and apoptosis. TGF- signaling promotes growth and development during early embryogenesis. However, in mature ...
Telomerase is a specialized ribonucleoprotein composed of telomerase reverse transcriptase (TERT), an intrinsic RNA template (TR), and several associated proteins. Its main function is to stabilize telomeres, which protect chromosomes from recombination and end-to-end fusion.
Telomeres also recognize DNA damage and control the replicative capability of cells. With each cell division some of ...
Cyclooxygenases (COXs), also known as prostaglandin H synthases, are fatty acid oxygenases that contain about 600 amino acid residues and act on arachidonic acid to generate prostaglandins (PG). All vertebrates contain two COX genes: one encoding the constitutive COX-1 and another inducible COX-2. COX-1 and COX-2 share approximately 60-65% amino acid identity. These COX isoforms are bifunctional ...
In unstressed cells, p53 is latent and is maintained at low levels by targeted degradation mediated by MDM2. Through its binding to p53, MDM2 can shuttle p53 out of the nucleus into the cytoplasm for degradation. When normal mammalian cells are subjected to stress signals, such as hypoxia, radiation, and chemotherapeutic drugs, p53 is phosphorylated at multiple sites, including those involved in ...
Part 2 Why Products Get Contaminated and What To Do About It.
Part 1 of this article discussed basic microbiology related to the manufacturing plant environment and consumer product formulations. Part 2 will discuss what to do when a finished product contamination occurs, and suggest how to investigate and track the problem. The article will also provide some tips on how to come to a final ...
Viscira is dedicated to the development of new media communication solutions and interactive software applications for the life sciences industry. The ...
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