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Toxicology Testing

    
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CNBE  CNBE is a CRO specialized in exploratory animal studies: toxicity, PK and drug efficacy studies in numerous animal models (rodents, rabbits, cotton rats, ferrets, farm animals, dogs and non-human primates). CNBE is GAP...
 
CNBE Animal facility description CNBE is GAP (Good Animal Practice) certified and has CCAC and AAALAC accreditations. CNBE has 78 multifunctional animal housing rooms (130,000 sq. ft.) for...
 
CNBE Detailled CRO services CNBE offers turnkey contract research in 1. toxicity (DRF, MTD, NOAEL, NOEL), 2. pharmacokinetic and 3. drug efficacy (proof-of-concept) in many areas...
 
Myriad RBM, Inc.  Myriad RBM is a CLIA-certified biomarker testing laboratory specializing in cost-effective, high-quality multiplexing services. Our protein immunoassays benefit drug discovery & development from preclinical through Phase...
 
Services Provided Myriad RBM, Inc. is the world’s leading multiplexed immunoassay testing laboratory, providing comprehensive protein biomarker services based on its...
BASi - Bioanalytical Systems, Inc.  bioanalytical sample analysis automated in-vivo blood sampling toxicology pharmaceutical analysis electrochemistry EC liquid chromatography LC Vetronics
 
Preclinical Toxicology Services Our AAALAC-accredited laboratory has been providing clients with drug safety and toxicology data for over 30 years. Located on a 52-acre campus in a rural...
Pacific BioLabs (PBL)  Pacific BioLabs is a contract research organization (CRO) offering testing and research support services to its clients in the medical device, pharm/biopharm, and other industries. Specializing in the biological sciences,...
 
PHARMACOKINETICS AND RADIOLABELED ADME Pharmacokinetic studies are used to gather information on how a drug compound moves through and is processed by the body. This includes the absorption,...
Avomeen Analytical Services  DEA Licensed, cGMP Compliant, and FDA Registered testing laboratory. Specializes in deformulation, materials identification, pharmaceutical development, cosmetics product testing, litigation support. Instrumentation...
 
Avomeen Scientific Expert Witness Capabilities Chemistry Expert Witnesses •Organic/Inorganic Ph.D. Chemists •Polymer and Analytical Chemistry •Failure Analysis •Deformulation •Material...
 
Chemistry Expert Witness The right legal support team makes all the difference. Avomeen’s Ph.D. expert witnesses have decades of experience handling complex legal cases such as...
 
Metrics, Inc  Metrics Inc. is a CDMO offering contract pharmaceutical research, pharmaceutical development, clinical trial and commercial manufacturing services. Metrics provides FTIM development and Phase I, II and III CTM.
 
Formulations Development Metrics provides pharmaceutical product development including pre-formulation studies, formulation development, Clinical trial batch manufacturing and...
 
Raw Material Release Compendial testing for USP/NF, BO, EP, JP and ACS monographs.
Advanced Chemistry Development (ACD/Labs)  ACD/Labs develops enterprise solutions and desktop software for R&D. We provide vendor neutral analytical data processing and prediction, knowledge management, interactive reporting, chemical naming, and...
 
ACD/IXCR Intelligent Compound Recognition using component detection software and spectral matching capabilities.
Korea Institute of Toxicology  Korea Institute of Toxicology (KIT) is a non-clinical CRO offering a full range of non-clinical study services with high scientific standards and competitive prices to international partners. KIT has been GLP and AAALAC...
 
General Toxicology The most basic set of tests to evaluate the safety of pharmaceuticals, agricultural and industrial chemicals, and environmental pollutants are General...
 
Genetic Toxicology Genetic Toxicology evaluates the potential toxic effects of chemical, physical and biological agents on the heredity of living organisms. It focuses on the...
 
ILS  ILS was established as a multidisciplinary research organization to provide comprehensive support to federal and commercial clients in the environmental and health sciences. ILS couples scientific excellence with...
 
General Toxicology Services Administration of Test Article (e.g. oral, subcutaneous, intravenous, intradermal, intratracheal, high pressure tail vein injections, footpad, aspiration,...
 
Genetic and Molecular Toxicology The Genetic and Cellular Toxicology Program offers a battery of validated genetic toxicology in vitro cell based assays and in vivo assays to meet ICH...
BioScience Laboratories, Inc.  A FDA / EPA registered, GLP and GCP, Microbiology, Virology, Toxicology analytical testing facility providing safety / efficacy / custom testing, product development, product differentiation, and regulatory consulting for...
Surgical Materials Testing Laboratory  The Surgical Materials Testing Laboratory (SMTL) is part of the Welsh NHS, funded by the Welsh Assembly Government, and based at Princess of Wales Hospital in Bridgend. Our core service is to provide medical device...
Seahorse Bioscience Inc  Bioscience provides industry-leading analytical instruments, biomanufacturing systems and consumable labware products for biological research and drug discovery.The customers include scientists at academic institutions,...
Transposagen Biopharmaceuticals  Transposagen Biopharmaceuticals, Inc., a Lexington, KY based company, is the worldwide leader in the creation of unique genetically modified knockout rat models, having created ~95% of the world’s existing inventory. The...
 
ErbB4 Knockout Rat Model v-erb-a erythroblastic leukemia viral oncogene homolog 4 TKO Knockout Rat created using Sleeping Beauty mobile DNA technology.
 
TKO Knockout Rat Models Laboratory rats with a single gene trap insertion created using mobile DNA technology
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Toxicology Testing - Product Reviews

New type of laboratory mice may be key to individualizing cancer treatment for sensitive individuals

Laboratories performing toxicity testing on chemotherapy drugs often find that, for some individuals, the treatment is as detrimental to health as the cancer itself.  "Adverse drug reactions can be difficult to study in humans," Jackson Laboratory scientist Dr. Gary Churchill says. "Every individual is genetically unique and lives in an uncontrolled environment. That's why we need animal model systems to fully understand the genetic basis of drug response.”

To better model human populations, Dr. Churchill co-designed a new strain of laboratory mice called Diversity Outbred or DO mice. These mice are quite different from the inbred or hybrid strains usually used in drug toxicity testing because each DO mouse has a unique genetic profile. The DNA of DO mice colonies display normal levels of heterozygosity, which approximates the genetic diversity in the human population better than the inbred varieties.

“Testing chemo drugs in DO mice will be almost like testing them in every person on Earth. This sets the scene for future, highly reliable screens for cancer patients," Dr. Churchill reports. This new approach may prove to be invaluable in improving therapy for individuals who are unable to tolerate a cancer-killing or other type of drug.


Best-in-Class Toxicology Testing:

  • Use healthy animals, which have not been previously involved in experiments and have had at least a 7-day acclimation period to laboratory conditions
  • Test protocol utilizes three or more dose levels and a control
  • Make sure that the highest dose level is enough to identify the toxic effects while avoiding severe toxicity, suffering or death


Top Considerations Before Selecting Toxicology Testing:

Much controversy surrounds animal testing, not only because of the suffering inflicted on the animals.  A number of scientists argue that progress is held back by using animal models, which they claim cannot reliably predict effects in humans. The three “R’s”: replacement, reduction and refinement, are principles adopted by many countries. “Replacement” options include in vitro cell culture techniques, in silico computer simulation, the use of humans for skin irritancy tests, donated human blood for pyrogenicity studies and microdosing, in which human volunteers receive doses well below those expected to produce whole-body effects. Investigating whether one of these methods represents a suitable alternative may end up yielding better results at a low cost.

Key Producers:

1. Rules-Based Medicine’s (RBM) Rat & Human KidneyMAP panels provide sensitive detection and quantitation of kidney damage caused by drug-induced renal toxicity, which is a leading cause of failure in drug development programs. These panels have the degree of sensitivity required to identify kidney damage before it becomes permanent. RBM reports that “Our proprietary Multi-Analyte Profiling (MAP) platform makes the drug discovery & development process more efficient and effective by providing pre-clinical and clinical researchers with reproducible, quantitative, multiplexed immunoassay data.” Corporate headquarters and CLIA-certified biomarker testing laboratory are in Austin, TX; multiplex assay development and manufacturing is in Lake Placid, NY and a subsidiary unit is located in Germany.

2. BIOCIUS Life Sciences, Inc.'s management team has extensive experience with toxicity testing. CEO Dr. Can C. Özbalis, who is responsible for much of the RapidFire® Lead Discovery development, earned a Ph.D. in Toxicology from Massachusetts Institute of Technology. RapidFire technology enables the screening of targets that are not amenable to fluorescence or luminescence. Biocius says that “RapidFire MS is 10 to 100 times faster than conventional MS screening methods.” This technology can either be used by the customer or provided as a contract research service. This privately held company is based in Wakefield MA and has a sales office in Switzerland.

3. The Jackson Laboratory offers state-of-the-art facilities, research support and a wide range of technologies, as well as mice colonies, to organizations around the world engaged in toxicity testing.  This company, which was started in 1929 as one of the first centers for cancer genetics research, is a major provider of genetic resources, software, and expertise to the scientific community. This independent, non-profit laboratory has two facilities in Maine and California and plans for a third in Florida, which will be funded by the state. The Jackson Laboratory also advances science by offering academic programs for teachers and students as well as for corporate researchers.

4. Geneva Laboratories, Inc. offers laboratory services, including toxicology testing, to the pharmaceutical and other industries. Geneva Labs has a 22,000 sq. ft. complex containing testing laboratories for Chemistry analysis, Microbiology and Biocompatibility, including six ISO Class 5 (Class 100) clean rooms as well as a 21,000 sq. ft. facility for special projects and stability studies. Geneva Laboratories is FDA registered, GLP compliant and certified to ISO 9001 and ISO 17025 standards. This company was started in 1976 and is headquartered in Elkhorn Wisconsin.

Toxicology Testing
Definition: Toxicity or toxicology testing, also known as safety testing, refers to the procedures used to determine whether drugs or other household products have adverse affects on living organisms.

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Toxicology Testing Research Library

Determination of an Acceptable Preservative for...
BASi - Bioanalytical Systems, Inc.
This method uses a 50:50 THF:water extraction solvent for the preparation of standards and samples. Preservative at a level of 0.1 weight percent in solution was added to stabilize the preparations. Analysis was accomplished by HPLC carried out on a Phenomenex Luna Phenyl Hexyl (150 x 4.6 mm) column at a flow rate of 1.0 mL/min. The separation was completed with a mobile phase of 35 mM ...
 
An Overview of Assay Quality Systems at Rules-Based Medicine
Myriad RBM, Inc.
Stringent guidelines of quality assurance and control (QA/QC) serve as the foundation for dependable and reproducible results in any analytical endeavor. Read step-by-step how the RBM platform combines the sensitivity and dynamic range of microsphere based immuno-multiplexing with the precision and dependability of automated liquid handling.
 
Testing of chemicals - fixed dose procedure
CNBE
Centre national de biologie expérimentale (CNBE) TESTING OF CHEMICALS – ACUTE ORAL TOXICITY «Testing of chemicals – acute oral toxicity» featured by CNBE INRS. Chemicals, through the different steps from their production to their handling, transport and use, represent a danger for human health. The acute oral toxicity testing of chemicals provides information on the hazardous properties and ...
 
Quality by Design: Method Development with ACD/AutoChrom MDS
Advanced Chemistry Development (ACD/Labs)
Quality by Design (QbD) was first described by Joseph M. Juran,[1] and applied with great success, particularly in the automotive industry. The underlying concept of QbD is that quality must be “designed in” to a product through the systematic implementation of a strategy to establish a complete understanding of the product and the processes used to develop and manufacture it. Control strategies ...
 
Triple Quadrupole Mass Spectrometer
Bruker BioSpin Corporation
A gAme chAnger creAtes such A disruptive AdvAntAge, it the eVoQ triple quadrupole for liquid chromatography (Lc-tQ) was designed for a singular purpose – to reliably quantify thousands of real samples in the fastest sample-to-report time possible. It delivers exceptional sensitivity, precision, accuracy, linearity, and a wide dynamic range for your multiple reaction monitoring (mrm) assays. ...
 

Toxicology Testing Video

Let's Work Together Metrics, Inc Meet some of the scientists of Metrics, Inc. a contract manufacturing organization (CMO).
 
Pacific BioLabs - A Bioscience Contract Research Organization Pacific BioLabs (PBL) Pacific BioLabs offers GLP/cGMP testing services to the biopharmaceutical, medical device, and combination product industries. PBL services include ...
 
Toxicology Testing CNBE Company

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