Rules-Based Medicine Rules-Based Medicine (RBM) is a CLIA-certified biomarker testing laboratory specializing in cost-effective, high-quality multiplexing services. Our protein immunoassays benefit drug discovery & development from...
Rat KidneyMAP
The RBM Rat KidneyMAP™ detects early signs of renal damage which is a common problem in drug development programs. Developed in conjunction with the...
RodentMAP
A 58-biomarker Multi-Analyte Profile (MAP) focused on the identification of biomarker patterns in rodent biological samples, such as serum or plasma. RBM's...
The Jackson Laboratory We help researchers discover treatments, preventions and cures for human disease through the provision of inbred, mutant and genetically engineered mouse models, research services, and comprehensive technical information...
Dow AgroSciences LLC Dow AgroSciences LLC, based in Indianapolis, Indiana, USA, is a top-tier agricultural company that combines the power of science and technology with the "Human Element" to constantly improve what is essential to human...
Taconic Taconic is dedicated to developing and delivering animal models and related laboratory services for the biomedical research community. We work closely with researchers to assure the integrity of their studies by...
Worldwide Primates, Inc. Worldwide Primates is a leading supplier of premium quality non-human primates, as well as primate biological products, and primate services.
Our Primates include Rhesus & Cynomolgus Monkeys, Marmosets, Baboons, and more.
African Green Monkeys
Worldwide Primates is a leading supplier of premium quality non-human primate models for research, including government, university, and pharmaceutical...
Baboons
Worldwide Primates is a leading supplier of premium quality non-human primate models for research, including government, university, and pharmaceutical...
Capuchins
Worldwide Primates is a leading supplier of premium quality non-human primate models for research, including government, university, and pharmaceutical...
Transposagen Biopharmaceuticals Transposagen is the worldwide leader in the creation of unique genetically modified knockout rat models. Over 100 TKO knockout rat lines have been created including the world's first SCID rat. TKO Knockout Rats are used...
ErbB4 Knockout Rat Model
v-erb-a erythroblastic leukemia viral oncogene homolog 4 TKO Knockout Rat created using Sleeping Beauty mobile DNA technology.
piggyBac iPS Technology
piggyBac has other applications including reprogramming fibroblasts to induced pluripotent stem (iPS) cells. These non-embryonic stem cells share most of...
TGEM Rat Models
Laboratory rats with a genetic mutation not created by a gene trap insertion.
Bayer HealthCare LLC Bayer HealthCare is among the world’s foremost innovators in the field of pharmaceutical and medical products. This subgroup’s mission is to research, develop, manufacture and market innovative products that improve the...
A preliminary study was conducted to determine the binding of [14C]warfarin to plasma proteins of human and laboratory animal species and protein solutions using ultrafiltration. [14C]Warfarin was 99.1, 98.9, 97.7, 94.2, 91.9 and 89.1% bound to plasma proteins of human, monkey, rat, rabbit, dog and mouse, respectively (average of the two genders). [14C]Warfarin was highly bound to HAS (99.0%) and ...
The RealBio™D4 Culture System Technology Overview
INTRODUCTION The RealBio™D4 Culture System is a revolutionary new tool that permits scientists to culture tissues and cells in an in vitro arrangement that mimics the natural in vivo composition, configuration and function of tissues. The system is a valuable tool for investigators across a broad range of disciplines including cell biologists, ...
The word biocompatibility refers to the interaction between a medical device and the tissues and physiological systems of the patient treated with the device. An evaluation of biocompatibility is one part of the overall safety assessment of a device. Biocompatibility of devices is investigated using analytical chemistry, in vitro tests, and animal models, in vivo tests. The biocompatibility of a ...
In the manufacture of potent active pharmaceutical ingredients (APIs) and products, there is a need to conduct qualitative and/or quantitative healthbased risk assessments for both occupational and product (patient) safety purposes. When performed from an occupational standpoint, qualitative health-based risk assessments involve the categorization (“banding”) of the API based on toxicity and ...
In vitro:in vivo Correlation: Topical Delivery Review of the literature of the past 40+ years reveals the great extent to which our understanding of the fun- damentals of percutaneous absorption depends upon a simple, yet multifaceted, model system: the in vitro use of excised animal or human skin mounted as a barrier be- tween two glass chambers. For those who believe that data obtained in vitro ...
The Food, Drug and Cosmetic Act requires that a drug be the subject of an approved marketing application before it is transported or distributed across state lines. A sponsor however will want to ship an investigational drug to clinical investigators in many states; it must seek an exemption from that legal requirement. The Investigational New Drug Application (IND) obtains this exemption from ...
Introduction The under treatment of post operative pain has been recognized to delay patient recovery and discharge from hospital. Despite recognition of the importance of effec- tive pain control, up to 70% of patients still complain of moderate to severe pain post operatively1.The most commonly used model to test the effect of new analgesic drugs in post operative pain is the Brennan model in ...
Food safety elisa test kit 1.Aminohydantion(AHD)Elisa test kit 2.Ampicillin Elisa test kit 3.Benzyl penicillin Elisa test kit 4.Chloramphenicol(CAP)Elisa test kit 5.Clenbuterol (Cle)Elisa test kit 6.Diazepam Elisa test kit 7.Diethylstilbestrol(DES)Elisa test kit 8.Enrofloxacin Elisa test kit 9.Florfenicol Elisa test kit 10.Gentamicin Elisa test kit 11.Malachite green Elisa test kit ...
The purpose of this document is to recommend international standards for and to promote harmonization of the nonclinical safety studies needed to support human clinical trials of a given scope and duration. Harmonization of the guidance for nonclinical safety studies will help to define the current recommendations and reduce the likelihood that substantial differences will exist between regions. ...
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![Inter-Species Comparison of In Vitro Plasma Protein Binding of [14C] Warfarin Using Ultrafiltration](/css/buyerportal/images/icon_pdf_73x91.png "Inter-Species Comparison of In Vitro Plasma Protein Binding of [14C] Warfarin Using Ultrafiltration"){kind=icon}
