Rules-Based Medicine Rules-Based Medicine (RBM) is a CLIA-certified biomarker testing laboratory specializing in cost-effective, high-quality multiplexing services. Our protein immunoassays benefit drug discovery & development from...
Rat KidneyMAP
The RBM Rat KidneyMAP™ detects early signs of renal damage which is a common problem in drug development programs. Developed in conjunction with the...
Rat MetabolicMAP
A 21-biomarker Multi-Analyte Profile (MAP) designed by a major pharmaceutical company to identify metabolic biomarker patterns in rat biological samples,...
RodentMAP
A 58-biomarker Multi-Analyte Profile (MAP) focused on the identification of biomarker patterns in rodent biological samples, such as serum or plasma. RBM's...
Bridge Laboratories Bridge is a preclinical CRO that provides US-level regulatory compliant toxicology services. Headquartered in Gaithersburg, Maryland, with lab facilities in the US and China; Bridge specializes in vaccines, DART,...
Safety Pharmacology
Bridge performs the following types of safety pharmacology studies, in both large and small animals: Core Battery Tests (CNS, Cardiovascular–Telemetry,...
The Jackson Laboratory We help researchers discover treatments, preventions and cures for human disease through the provision of inbred, mutant and genetically engineered mouse models, research services, and comprehensive technical information...
Taconic Taconic is dedicated to developing and delivering animal models and related laboratory services for the biomedical research community. We work closely with researchers to assure the integrity of their studies by...
Cytochrome P450s (CYP450) mediate the biotransformation of drug compounds. Metabolism of multiple test compounds by the same CYP450 isoform can alter reaction kinetics and result in adverse drug-drug interactions (DDI). Therefore, high throughput-DDI assays are valuable tools in the go/no-go decision-making process in drug discovery. Mass spectrometry-based CYP450 assays have emerged as the ...
Recent industry analyst reports predict that worldwide pharmaceutical industry revenues will grow at a compound annual growth rate (CAGR) of 8.58% through 2008. Worldwide biotechnology revenues are expected to grow at a compound annual growth rate of 25.96% through 2008 – this large growth rate is not surprising as many biotechnology and biopharmaceutical companies are just now moving products ...
This paper explores the opportunities to improve the R&D process. It proposes new technologies will enable the adoption of virtual R&D; and by operating in a more connected world, the industry in collaboration with researchers, governments, healthcare payers and providers, can address the changing needs of society more effectively.
Epidemiologic analysis has revealed the association of psoriasis with inflammatory bowel disease (IBD) in humans. In mice, transfer of CD45RBhi CD4+ naive T cells into immunodeficient animals induces colitis and psoriasis-like phenotypes. This sample study describes the utility of such an adoptive transfer model to evaluate novel compounds for the treatment of IBD and psoriasis.
Introduction The under treatment of post operative pain has been recognized to delay patient recovery and discharge from hospital. Despite recognition of the importance of effec- tive pain control, up to 70% of patients still complain of moderate to severe pain post operatively1.The most commonly used model to test the effect of new analgesic drugs in post operative pain is the Brennan model in ...
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