Cryopreservation Services
Research Library
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The Jackson Laboratory
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Epidemiologic analysis has revealed the association of psoriasis with inflammatory bowel disease (IBD) in humans. In mice, transfer of CD45RBhi CD4+ naive T cells into immunodeficient animals induces colitis and psoriasis-like phenotypes. This sample study describes the utility of such an adoptive transfer model to evaluate novel compounds for the treatment of IBD and psoriasis.
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EMD Chemicals Inc.
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Transforming growth factor- (TGF-), a member of the TGF superfamily of proteins that includes activins, inhibins, and bone morphogenetic proteins (BMPs), regulates a wide array of cellular processes including cell differentiation, cellular senescence, immune response, wound healing, and apoptosis. TGF- signaling promotes growth and development during early embryogenesis. However, in mature ...
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EMD Chemicals Inc.
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Telomerase is a specialized ribonucleoprotein composed of telomerase reverse transcriptase (TERT), an intrinsic RNA template (TR), and several associated proteins. Its main function is to stabilize telomeres, which protect chromosomes from recombination and end-to-end fusion.
Telomeres also recognize DNA damage and control the replicative capability of cells. With each cell division some of ...
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EMD Chemicals Inc.
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Cyclooxygenases (COXs), also known as prostaglandin H synthases, are fatty acid oxygenases that contain about 600 amino acid residues and act on arachidonic acid to generate prostaglandins (PG). All vertebrates contain two COX genes: one encoding the constitutive COX-1 and another inducible COX-2. COX-1 and COX-2 share approximately 60-65% amino acid identity. These COX isoforms are bifunctional ...
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EMD Chemicals Inc.
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In unstressed cells, p53 is latent and is maintained at low levels by targeted degradation mediated by MDM2. Through its binding to p53, MDM2 can shuttle p53 out of the nucleus into the cytoplasm for degradation. When normal mammalian cells are subjected to stress signals, such as hypoxia, radiation, and chemotherapeutic drugs, p53 is phosphorylated at multiple sites, including those involved in ...
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