Rules-Based Medicine Rules-Based Medicine (RBM) is a CLIA-certified biomarker testing laboratory specializing in cost-effective, high-quality multiplexing services. Our protein immunoassays benefit drug discovery & development from...
The Jackson Laboratory We help researchers discover treatments, preventions and cures for human disease through the provision of inbred, mutant and genetically engineered mouse models, research services, and comprehensive technical information...
Absorption Systems LP Absorption Systems is a contract research organization founded in 1996 by Patrick M. Dentinger and Ismael J. Hidalgo, Ph.D. Patrick, President and CEO, handles the business side of the company, while Ismael is the Chief...
Excretion
We routinely run assays for our customers that determine:
P-gp mediated efflux by MDR1-MDCK cells in vitro,
the rate and extent to which a compound appears...
Bioanalytical Systems, Inc. BASi, then known as Bioanalytical Systems, Inc., was created, literally, in the garage of Dr. Peter Kissinger in 1974. A few years later, he was joined in the enterprise by his wife Candice and together they lead BASi...
Apredica Apredica provides preclinical contract testing services for the evaluation and optimization of the ADME, Toxicity, and Pharmacokinetic properties of drug candidates early in the drug-discovery process.
Frontage Laboratories, Inc. Early stage, contract development from DMPK, formulation development, GMP CTM, analytical, bioanalytical and clinical trial services for small and large molecules
Pre-Market Testing for Cosmetic and Personal Care Products Requirements for Safety Efficacy and Maintaining Product Integrity
By Bradford Rope, President BioScreen Testing Services, Inc. What could be more important than protecting your trademark and good name of your company? Anyone can purchase a formula in a bottle, but the knowledge of how to protect your investment can make or break your ...
At no additional cost to clients, Lancaster Laboratories streamlines Raw Materials testing expressly for certain routine USP and EP tests. Have results in 5 days if compendia methodology and noncustomized documentation formats suit your project needs. And with LabAccess.com, our 24/7 web portal, view all your data such as analysts' notebooks, chromatograms, and individual test results as your ...
Actril Cold Sterilant is an US EPA registered disinfectant that has a broad range of disinfection claims. Actril Cold Steril- ant is used in a wide range of healthcare and clean room facilities. This technical white paper examines the use of Actril Cold Sterilant in a pharmaceutical manufacturing en- vironment that complies with USP-NF <1072>: Disinfectants and Antiseptics.
Actril Cold Sterilant ...
With the worldwide rise of obesity and metabolic diseases, labs should conduct ongoing test monitoring to see what may be of value for obesity. This report covers which tests are well-established and which provide beneficial results.
Part 2 Why Products Get Contaminated and What To Do About It.
Part 1 of this article discussed basic microbiology related to the manufacturing plant environment and consumer product formulations. Part 2 will discuss what to do when a finished product contamination occurs, and suggest how to investigate and track the problem. The article will also provide some tips on how to come to a final ...
Microalbuminuria is an important and well established biomarker in patients with type 2 diabetes, due to its association with progressive renal disease. However, recent studies suggest that microalbuminuria may be considered as an independent marker for cardiovascular disease in patients with hypertension as well as diabetes(1,2,3) the prevalence increasing with age and duration of hypertension.
Apomorphine is under investigation for the treatment of erectile dysfunction. The excretion and metabolism of apomorphine were investigated after administration of a single sublingual dose of [14C]apomorphine (1.94 mg, approximately 80 µCi 14C, as an aqueous solution) to six healthy male subjects. Whole blood, plasma, urine and feces samples were collected at designated times during a 7-day ...
Purpose: J867 is a novel selective progesterone receptor modulator (SPRM).The purpose of this study was to investigate the absorption and excretion of radioactivity after administration of a single intravenous (IV) or oral (PO) dose of [14C]J867 to rats, mice and monkeys.
Methods: [14C]J867 was administered at ~5 mg/Kg BW in a single IV or PO dose to noncannulated or bile duct-cannulated ...
Apomorphine is under investigation for the treatment of male erectile dysfunction.The mass balance and excretion of radioactivity were investigated after a single subcutane- ous administration of [14C]apomorphine to rats (0.26 mg apomorphine base/kg), mice (9.48 mg apomorphine base/kg) and dogs (0.35 mg apomorphine base/kg). Urine, feces, and cage washes were collected at various time intervals ...
Prediction of the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of compounds in pharmaceutical development are essential aspects of the drug discovery process. B-CLEAR® (sandwich-cultured hepatocytes) is an in vitro system that is used to analyze and predict the in vivo hepatobiliary disposition (hepatic uptake, biliary excretion, and biliary clearance) and ...
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