Rules-Based Medicine Rules-Based Medicine (RBM) is a CLIA-certified biomarker testing laboratory specializing in cost-effective, high-quality multiplexing services. Our protein immunoassays benefit drug discovery & development from...
BIOCIUS Life Sciences (formerly BioTrove RapidFire) RapidFire technology enables the acceleration of drug discovery pipeline decisions. Used by 13 of the top 15 pharma companies, RapidFire instrumentation and screening services help to eliminate bottlenecks in drug...
BIOCIUS Lead Discovery Services
After a target is selected, BioTrove’s experienced scientists develop and optimize proprietary RapidFire screening methods. These assays may then be used in...
The Jackson Laboratory We help researchers discover treatments, preventions and cures for human disease through the provision of inbred, mutant and genetically engineered mouse models, research services, and comprehensive technical information...
High Throughput Genomics High Throughput Genomics, Inc. (HTG) provides gene expression and high throughput screening products and services based upon the quantitative nuclease expression (qNPA) technology. When matched with our ArrayPlate...
NAMSA NAMSA, North American Science Associates, medical device testing, medical device safety evaluation, medical devices, testing laboratory, contract research organization, medical device contract research organization
Cytochrome P450s (CYP450) mediate the biotransformation of drug compounds. Metabolism of multiple test compounds by the same CYP450 isoform can alter reaction kinetics and result in adverse drug-drug interactions (DDI). Therefore, high throughput-DDI assays are valuable tools in the go/no-go decision-making process in drug discovery. Mass spectrometry-based CYP450 assays have emerged as the ...
Epidemiologic analysis has revealed the association of psoriasis with inflammatory bowel disease (IBD) in humans. In mice, transfer of CD45RBhi CD4+ naive T cells into immunodeficient animals induces colitis and psoriasis-like phenotypes. This sample study describes the utility of such an adoptive transfer model to evaluate novel compounds for the treatment of IBD and psoriasis.
Telomerase is a specialized ribonucleoprotein composed of telomerase reverse transcriptase (TERT), an intrinsic RNA template (TR), and several associated proteins. Its main function is to stabilize telomeres, which protect chromosomes from recombination and end-to-end fusion.
Telomeres also recognize DNA damage and control the replicative capability of cells. With each cell division some of ...
Transforming growth factor- (TGF-), a member of the TGF superfamily of proteins that includes activins, inhibins, and bone morphogenetic proteins (BMPs), regulates a wide array of cellular processes including cell differentiation, cellular senescence, immune response, wound healing, and apoptosis. TGF- signaling promotes growth and development during early embryogenesis. However, in mature ...
Cyclooxygenases (COXs), also known as prostaglandin H synthases, are fatty acid oxygenases that contain about 600 amino acid residues and act on arachidonic acid to generate prostaglandins (PG). All vertebrates contain two COX genes: one encoding the constitutive COX-1 and another inducible COX-2. COX-1 and COX-2 share approximately 60-65% amino acid identity. These COX isoforms are bifunctional ...
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