Rules-Based Medicine Rules-Based Medicine (RBM) is a CLIA-certified biomarker testing laboratory specializing in cost-effective, high-quality multiplexing services. Our protein immunoassays benefit drug discovery & development from...
amsbio AMS Biotechnology, Leading developing modern products and technologies for life science research: Antibody, Protein, Peptide, Apoptosis, Migration, Cell Proliferation kits and reagents, Cytokines, Protein Kinases,...
The Jackson Laboratory We help researchers discover treatments, preventions and cures for human disease through the provision of inbred, mutant and genetically engineered mouse models, research services, and comprehensive technical information...
Capital Biosceinces Capital Biosciences, Inc. offers a variety of biological products including Cell Immortalization Products, Clinically Defined Human Tissue, cDNA ORF Clones, Premade Adenoviruses, Purified Proteins, Viral Expression...
Accumbens- left, Normal FFPE tissue
CBI provides normal human tissue from a clinically-unremarkable donor. Preparation: FFPE block. Tissue is prepared by a certified medical pathologist, fixed...
Accumbens- left, Normal OCT frozen tissue
CBI provides normal human tissue from a clinically-unremarkable donor. Preparation: OCT embedded tissue (one block) prepared by a certified histologist....
Accumbens- left, Normal snap-frozen tissue
CBI provides normal human tissue from a clinically-unremarkable donor. Preparation: snap-frozen tissue. Tissue (0.5 -1 gram) is prepared by a certified...
Asterand, plc Asterand plc is the leading global supplier of high quality, well characterized human tissue and human tissue-based research services to pharmaceutical and biotechnology companies engaged in drug discovery research.
Epidemiologic analysis has revealed the association of psoriasis with inflammatory bowel disease (IBD) in humans. In mice, transfer of CD45RBhi CD4+ naive T cells into immunodeficient animals induces colitis and psoriasis-like phenotypes. This sample study describes the utility of such an adoptive transfer model to evaluate novel compounds for the treatment of IBD and psoriasis.
In unstressed cells, p53 is latent and is maintained at low levels by targeted degradation mediated by MDM2. Through its binding to p53, MDM2 can shuttle p53 out of the nucleus into the cytoplasm for degradation. When normal mammalian cells are subjected to stress signals, such as hypoxia, radiation, and chemotherapeutic drugs, p53 is phosphorylated at multiple sites, including those involved in ...
Cyclooxygenases (COXs), also known as prostaglandin H synthases, are fatty acid oxygenases that contain about 600 amino acid residues and act on arachidonic acid to generate prostaglandins (PG). All vertebrates contain two COX genes: one encoding the constitutive COX-1 and another inducible COX-2. COX-1 and COX-2 share approximately 60-65% amino acid identity. These COX isoforms are bifunctional ...
Transforming growth factor- (TGF-), a member of the TGF superfamily of proteins that includes activins, inhibins, and bone morphogenetic proteins (BMPs), regulates a wide array of cellular processes including cell differentiation, cellular senescence, immune response, wound healing, and apoptosis. TGF- signaling promotes growth and development during early embryogenesis. However, in mature ...
Telomerase is a specialized ribonucleoprotein composed of telomerase reverse transcriptase (TERT), an intrinsic RNA template (TR), and several associated proteins. Its main function is to stabilize telomeres, which protect chromosomes from recombination and end-to-end fusion.
Telomeres also recognize DNA damage and control the replicative capability of cells. With each cell division some of ...
Affordable semi-automated (Click’n’Count) and automated (SuperCount), the aCOLyte colony counting systems greatly improve efficiency, reliability and ...
The MICROLAB® NIMBUS is Hamilton Company's newest automated multi-channel pipetting platform, offering a high density deck layout in a body small enough ...
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