Rules-Based Medicine Rules-Based Medicine (RBM) is a CLIA-certified biomarker testing laboratory specializing in cost-effective, high-quality multiplexing services. Our protein immunoassays benefit drug discovery & development from...
Human MetabolicMAP
A 21-biomarker Multi-Analyte Profile (MAP) focused on the elucidation of metabolic biomarker patterns in a biological sample, such as serum or plasma. ...
Rat MetabolicMAP
A 21-biomarker Multi-Analyte Profile (MAP) designed by a major pharmaceutical company to identify metabolic biomarker patterns in rat biological samples,...
The Jackson Laboratory We help researchers discover treatments, preventions and cures for human disease through the provision of inbred, mutant and genetically engineered mouse models, research services, and comprehensive technical information...
Absorption Systems At Absorption Systems, our mission is to find and execute the most appropriate solution to answer your ADME questions. We are problem-solvers: we listen, come up with the most appropriate preclinical model to address the...
Metabolism
Absorption Systems uses both in vitro and in vivo metabolism models to characterize the metabolic stability and metabolic fate of our customers'...
Metabolite Identification
As part of our drug metabolism program, Absorption Systems has a QTRAP and experienced analytical chemists who perform metabolite ID. We take a tiered...
Aptuit As the global leader in integrated pharmaceutical development services, Aptuit's suite of capabilities and wealth of expertise will speed your drug development process from discovery to launch.
Our ongoing commitment to...
Aptuit Drug Metabolism and Pharmacokinetics
Our Drug Metabolism and Pharmacokinetics department offers a full and comprehensive service for both in vitro and in vivo studies in support of IND, CTA and...
Aptuit INDiGO™
Although the industry has seen an increase in overall R&D spending the number of novel compounds making it to market has decreased. Drug innovators are...
Aptuit Preclinical and Clinical Technologies
Aptuit’s Bioanalysis group provides dedicated expertise and practical support for our in-house integrated preclinical packages for drug development. We also...
Epidemiologic analysis has revealed the association of psoriasis with inflammatory bowel disease (IBD) in humans. In mice, transfer of CD45RBhi CD4+ naive T cells into immunodeficient animals induces colitis and psoriasis-like phenotypes. This sample study describes the utility of such an adoptive transfer model to evaluate novel compounds for the treatment of IBD and psoriasis.
Cyclooxygenases (COXs), also known as prostaglandin H synthases, are fatty acid oxygenases that contain about 600 amino acid residues and act on arachidonic acid to generate prostaglandins (PG). All vertebrates contain two COX genes: one encoding the constitutive COX-1 and another inducible COX-2. COX-1 and COX-2 share approximately 60-65% amino acid identity. These COX isoforms are bifunctional ...
Telomerase is a specialized ribonucleoprotein composed of telomerase reverse transcriptase (TERT), an intrinsic RNA template (TR), and several associated proteins. Its main function is to stabilize telomeres, which protect chromosomes from recombination and end-to-end fusion.
Telomeres also recognize DNA damage and control the replicative capability of cells. With each cell division some of ...
Transforming growth factor- (TGF-), a member of the TGF superfamily of proteins that includes activins, inhibins, and bone morphogenetic proteins (BMPs), regulates a wide array of cellular processes including cell differentiation, cellular senescence, immune response, wound healing, and apoptosis. TGF- signaling promotes growth and development during early embryogenesis. However, in mature ...
In unstressed cells, p53 is latent and is maintained at low levels by targeted degradation mediated by MDM2. Through its binding to p53, MDM2 can shuttle p53 out of the nucleus into the cytoplasm for degradation. When normal mammalian cells are subjected to stress signals, such as hypoxia, radiation, and chemotherapeutic drugs, p53 is phosphorylated at multiple sites, including those involved in ...
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