Rules-Based Medicine Rules-Based Medicine (RBM) is a CLIA-certified biomarker testing laboratory specializing in cost-effective, high-quality multiplexing services. Our protein immunoassays benefit drug discovery & development from...
The Jackson Laboratory We help researchers discover treatments, preventions and cures for human disease through the provision of inbred, mutant and genetically engineered mouse models, research services, and comprehensive technical information...
BioMICADAS
In addition, Vitalea offers the following hybridized approach to ADME where we cover the full range of 14C concentrations using AMS and Liquid Scintillation...
xCeleron Founded in 1997 in York, UK, Xceleron provides bioanalytical Accelerator Mass Spectrometry (AMS) services for accelerated early drug development. The company uses ultra-sensitive AMS to investigate the pharmacokinetics...
MicroConstants MicroConstants is a GLP-compliant CRO providing bioanalytical, pharmacokinetics, drug metabolism, immunoassay, method development and sample analysis to support drug development.
Drug Metabolism (DMPK)
MicroConstants performs industry-standard assays, custom drug metabolism research and IND-enabling studies to assess drug-drug interaction potential,...
Absorption Systems LP Absorption Systems is a contract research organization founded in 1996 by Patrick M. Dentinger and Ismael J. Hidalgo, Ph.D. Patrick, President and CEO, handles the business side of the company, while Ismael is the Chief...
Metabolism
Absorption Systems uses both in vitro and in vivo metabolism models to characterize the metabolic stability and metabolic fate of our customers'...
Metabolite Identification
As part of our drug metabolism program, Absorption Systems has a QTRAP and experienced analytical chemists who perform metabolite ID. We take a tiered...
Bioanalytical Systems, Inc. BASi, then known as Bioanalytical Systems, Inc., was created, literally, in the garage of Dr. Peter Kissinger in 1974. A few years later, he was joined in the enterprise by his wife Candice and together they lead BASi...
Enoximone is a selective PDE-3 inhibitor currently in Phase III development for the treatment of advanced chronic heart failure. Enoximone is metabolized to the primary metabolite, enantiomeric enoximone sulfoxide, and it is important to determine if this conversion is stereoselective.
Apomorphine (5,6,6a,7-tetrahydro-6-methyl-4H- dibenzo[de,g]quinoline-10,11-diol) is a dopamine receptor agonist under development for the treatment of erectile dysfunction.The purpose of this study was to characterize the in vitro metabolism of apomorphine by hepatocytes from human, rat, and dog. Solutions of 14C-labeled and nonradiolabeled apomorphine were incubated with primary hepatocytes at ...
Investigation of the metabolic pathways of new drug candi- dates using both in vitro and in vitro methods has become very important during drug development . The goal of this study was to profile and identify metabolites of apomor- phine, which is under investigation for the treatment of male erectile dysfunction, in both in vitro and in vitro gener- ated samples.
In vitro: The metabolism of ...
Purpose: To characterize the cytochrome 450 (CYP450) isoenzymes involved in the metabolism of brinzolamide by human liver microsomes using 1) Correlation analysis with typed human liver microsomes from individual livers, and 2) Inhibition with CYP450 isoenzyme-selective chemical inhibitors.
An LC-MS/MS method was developed for the quantitation of N-desethyl brinzolamide, O-desmethyl ...
Apomorphine is under investigation for the treatment of erectile dysfunction. The excretion and metabolism of apomorphine were investigated after administration of a single sublingual dose of [14C]apomorphine (1.94 mg, approximately 80 µCi 14C, as an aqueous solution) to six healthy male subjects. Whole blood, plasma, urine and feces samples were collected at designated times during a 7-day ...
Enoximone (4-methyl-5-[p-(methylthio)benzoyl]-4-im idazo- lin-2-one) is a selective PDE-3 inhibitor. Enoximone exerts its pharmacologic effects by inhibiting degradation of cyclic AMP to produce both positive inotropic and vasodilator ef- fects in subjects with advanced chronic heart failure.
The potential for drug-drug interactions must be deter- mined for drug candidates prior to submission ...
Introduction/Objectives:
-J867 is a novel selective progesterone receptor modulator (SPRM).
-Investigate the in vitro metabolism of J867 using hepatocytes and liver microsomes from male and femal human and various animal species.
-Characterize radioactivity in microsome and hepatocyte metabolites using HPLC-radiochromatography.
-Tentatively identify J867 metabolites by LC-MS/MS generated ...
Introduction / Objectives:
• J867 is a novel selective progesterone receptor modulator (SPRM).
• The disposition and metabolism of J867 were investigated after intravenous (IV) or oral (po) administration of [14C]J867 to male and female bile duct-cannulated Sprague-Dawley rats and CD-1 mice.
• Characterize the radioactivity in bile using HPLC- radiochromatography.
• Tentatively identify ...
Apomorphine is under investigation for the treatment of male erectile dysfunction.The disposition and metabolism of apomorphine were investigated after a single subcutaneous dose of [14C]apomorphine (0.34 mg apomorphine base/kg) to a bile duct-cannulated male dog. A total of 92.2% of the administered dose was recovered: 0.1% in plasma, 38.2% in bile, 51.2% in urine, 2.1% in feces, and 0.7% in ...
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