Rules-Based Medicine Rules-Based Medicine (RBM) is a CLIA-certified biomarker testing laboratory specializing in cost-effective, high-quality multiplexing services. Our protein immunoassays benefit drug discovery & development from...
Aniara ANIARA provides you with a comprehensive offering of diagnostic and research agents, as well as screening tools, all designed to meet today's highest standards for product quality. You can also rely on Aniara for highly...
READY TO USE ASSAYS
A FULL RANGE OF READY TO USE ASSAYS INCLUDING HEMOCLOT, CEPHEN, BIOPHEN, ZYMUPHEN, AND ZYMUEST PRODUCT LINES.
CLOTTING METHODS
HYPHEN BioMed offers a...
The Jackson Laboratory We help researchers discover treatments, preventions and cures for human disease through the provision of inbred, mutant and genetically engineered mouse models, research services, and comprehensive technical information...
BIOCIUS Life Sciences (formerly BioTrove RapidFire) RapidFire technology enables the acceleration of drug discovery pipeline decisions. Used by 13 of the top 15 pharma companies, RapidFire instrumentation and screening services help to eliminate bottlenecks in drug...
BIOCIUS Lead Discovery Services
After a target is selected, BioTrove’s experienced scientists develop and optimize proprietary RapidFire screening methods. These assays may then be used in...
Cytochrome P450s (CYP450) mediate the biotransformation of drug compounds. Metabolism of multiple test compounds by the same CYP450 isoform can alter reaction kinetics and result in adverse drug-drug interactions (DDI). Therefore, high throughput-DDI assays are valuable tools in the go/no-go decision-making process in drug discovery. Mass spectrometry-based CYP450 assays have emerged as the ...
Epidemiologic analysis has revealed the association of psoriasis with inflammatory bowel disease (IBD) in humans. In mice, transfer of CD45RBhi CD4+ naive T cells into immunodeficient animals induces colitis and psoriasis-like phenotypes. This sample study describes the utility of such an adoptive transfer model to evaluate novel compounds for the treatment of IBD and psoriasis.
In unstressed cells, p53 is latent and is maintained at low levels by targeted degradation mediated by MDM2. Through its binding to p53, MDM2 can shuttle p53 out of the nucleus into the cytoplasm for degradation. When normal mammalian cells are subjected to stress signals, such as hypoxia, radiation, and chemotherapeutic drugs, p53 is phosphorylated at multiple sites, including those involved in ...
Transforming growth factor- (TGF-), a member of the TGF superfamily of proteins that includes activins, inhibins, and bone morphogenetic proteins (BMPs), regulates a wide array of cellular processes including cell differentiation, cellular senescence, immune response, wound healing, and apoptosis. TGF- signaling promotes growth and development during early embryogenesis. However, in mature ...
Telomerase is a specialized ribonucleoprotein composed of telomerase reverse transcriptase (TERT), an intrinsic RNA template (TR), and several associated proteins. Its main function is to stabilize telomeres, which protect chromosomes from recombination and end-to-end fusion.
Telomeres also recognize DNA damage and control the replicative capability of cells. With each cell division some of ...
The G:BOX is a stunning new range of gel documentation (gel doc) and analysis systems for all imaging requirements.
The innovative design gives the user ...
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