Rules-Based Medicine Rules-Based Medicine (RBM) is a CLIA-certified biomarker testing laboratory specializing in cost-effective, high-quality multiplexing services. Our protein immunoassays benefit drug discovery & development from...
The Jackson Laboratory We help researchers discover treatments, preventions and cures for human disease through the provision of inbred, mutant and genetically engineered mouse models, research services, and comprehensive technical information...
MicroConstants MicroConstants is a GLP-compliant CRO providing bioanalytical, pharmacokinetics, drug metabolism, immunoassay, method development and sample analysis to support drug development.
Pharmacokinetic Analysis
MicroConstants specializes in conducting pharmacokinetic data analysis for discovery, preclinical, clinical and GLP toxicology studies. We perform either...
Apredica Apredica provides preclinical contract testing services for the evaluation and optimization of the ADME, Toxicity, and Pharmacokinetic properties of drug candidates early in the drug-discovery process.
Tandem Labs Tandem Labs is a leading bioanalytical and immunoanalytical contract research organization (CRO) supporting pharmaceutical and biotechnology companies with their discovery, preclinical, and clinical drug development...
QPS QPS is a global GLP-compliant contract laboratory supporting drug discovery and development. We have been providing high quality services to pharmaceutical and biotechnology clients worldwide since 1995. Our four areas of...
xCeleron Founded in 1997 in York, UK, Xceleron provides bioanalytical Accelerator Mass Spectrometry (AMS) services for accelerated early drug development. The company uses ultra-sensitive AMS to investigate the pharmacokinetics...
An HPLC-MS/MS method was developed and validated for rifabutin in plasma with a linear range of 5.00 to 800 ng/mL. Rifabutin is a semisynthetic antibacterial agent for use against diseases such as Mycobacterium-avium complex in HIV-positive patients. The HPLC-MS/MS method developed was validated for the determination of rifabutin in human plasma.
An LC-MS/MS method was developed and validated for the determination of aripiprazole (OPC-14597) and its metabolites in human urine.The method employed C-18 SPE, followed by LC-MS/MS. Aripiprazole is under investigation for use in the treatment of schizophrenia.
An LC-MS/MS method was developed and validated for the determination of cilostazol (OPC-13013) and its metabolites in human plasma.The method employed liquid-liquid partition, C-18 SPE, followed by LC-MS/MS. Cilostazol is under investigation for use in the treatment of intermittent claudication.
To develop and validate a sensitive and reproducible LC-MS/MS assay for the determination of cyclic guanosine monophosphate (cGMP) in potassium EDTA human plasma containing aprotinin. cGMP is know to relax vascular smooth muscle tissue which leads to vasodilation and increased blood-flow to the tissue. Drugs found to increase cGMP levels have been investigated and developed. Monitoring the levels ...
Although children suffer from many of the same diseases as adults and are often treated with the same drugs, only a small fraction of the drugs marketed and used as therapies in the United States have been studied in pediatric patients 0–16 years of age. Recent data demonstrates that only about 25% of approved drugs marketed in the United States have adequate pediatric data to support approval of ...
DOI:10.1111/j.1365-2125.2005.02542.x British Journal of Clinical Pharmacology
Pharmacokinetics of a new testosterone transdermal
delivery system, TDS®-testosterone in healthy males
Z. Chik,1 A. Johnston,1 A. T. Tucker,1,2 S. L. Chew,3 L. Michaels4 & C. A. S. Alam5 1Clinical Pharmacology, 5Experimental Pathology, 3Endocrinology, William Harvey Research Institute, Barts and The London, Queen ...
A Randomised, Single-Dose, Two-Period, Cross-Over Phase I Pharmacokinetic Study to Compare TDS®-Diazepam with Rectal Diazepam in Healthy Adult Subjects.
F Al-Otaibi1, A Johnston1, AT Tucker1,2, T Lee3, R Langford1,4, K Kirby6, S Ratcliffe4, CAS Alam5
1Clinical Pharmacology, 5Experimental Pathology, WHRI, QMUL; 2Clinical Vascular & Microvascular Unit, and 4Anaesthetics Department, Barts and The ...
To develop and validate an LC-MS/MS method for the determination of cortisol in human saliva containing 1.5 mM citric acid. Among other functions, cortisol serves to help the body manage stress and has been termed “the stress hormone” because it is also secreted in higher levels during the body’s response to stress. Therefore, the levels of cortisol can be used as a biomarker and pharmacodynamic ...
Importance of the eld: Understanding fully the mechanism(s) of action of current and novel anticancer drugs is essential to optimize treatment regimens for oncology patients, to improve or extend drug efcacy and reduce patient side effects. Nucleoside analogues, either alone or in combination with addi- tional therapeutic agents, are an essential part of rst-line and salvage regimens directed ...
Conducting comprehensive metabolism studies has long been an essential component of a preclinical drug development program. However, numerous factors — including the increased development of protein-derived drugs and the expanded interest in the role of metabolites in safety assessment — are having a significant impact on the regulatory mandates, scope of studies and methodologies employed. In ...
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