Rules-Based Medicine Rules-Based Medicine (RBM) is a CLIA-certified biomarker testing laboratory specializing in cost-effective, high-quality multiplexing services. Our protein immunoassays benefit drug discovery & development from...
LAB Research LAB Research is a leading in-vivo nonclinical contract research organization with facilities in Canada, Hungary and Denmark. LAB Research strength is in our skilled people and a core focus in drug development services and...
The Jackson Laboratory We help researchers discover treatments, preventions and cures for human disease through the provision of inbred, mutant and genetically engineered mouse models, research services, and comprehensive technical information...
ABC Laboratories ABC Laboratories is a drug development partner that understands what you need from an outsourcing relationship: technical expertise, effective communication and on-time, reliable results. With recent investments in...
ABC Bioanalytical Testing
ABC Laboratories offers dose formulation and routine bioanalytical testing for preclinical through Phase III clinical trials. Our bioanalytical team has...
ABC DMPK in-vivo Services
ABC Laboratories provides GLP services for PK, ADME and bioanalysis to support IND-enabling programs. Our unique combination of radio-labeling expertise,...
Frontage Laboratories ABR is a full-service, Phase I-IV global CRO dedicated to meeting the needs of pharmaceutical, biotechnology, and medical device companies. ABR offers an extensive range of clinical services including clinical study...
Frontage GLP Toxicology Studies
Toxicology is the study of the relationship between dose and its effects on the exposed organism. The chief criterion regarding the toxicity of a chemical...
Epidemiologic analysis has revealed the association of psoriasis with inflammatory bowel disease (IBD) in humans. In mice, transfer of CD45RBhi CD4+ naive T cells into immunodeficient animals induces colitis and psoriasis-like phenotypes. This sample study describes the utility of such an adoptive transfer model to evaluate novel compounds for the treatment of IBD and psoriasis.
Cyclooxygenases (COXs), also known as prostaglandin H synthases, are fatty acid oxygenases that contain about 600 amino acid residues and act on arachidonic acid to generate prostaglandins (PG). All vertebrates contain two COX genes: one encoding the constitutive COX-1 and another inducible COX-2. COX-1 and COX-2 share approximately 60-65% amino acid identity. These COX isoforms are bifunctional ...
In unstressed cells, p53 is latent and is maintained at low levels by targeted degradation mediated by MDM2. Through its binding to p53, MDM2 can shuttle p53 out of the nucleus into the cytoplasm for degradation. When normal mammalian cells are subjected to stress signals, such as hypoxia, radiation, and chemotherapeutic drugs, p53 is phosphorylated at multiple sites, including those involved in ...
Telomerase is a specialized ribonucleoprotein composed of telomerase reverse transcriptase (TERT), an intrinsic RNA template (TR), and several associated proteins. Its main function is to stabilize telomeres, which protect chromosomes from recombination and end-to-end fusion.
Telomeres also recognize DNA damage and control the replicative capability of cells. With each cell division some of ...
Transforming growth factor- (TGF-), a member of the TGF superfamily of proteins that includes activins, inhibins, and bone morphogenetic proteins (BMPs), regulates a wide array of cellular processes including cell differentiation, cellular senescence, immune response, wound healing, and apoptosis. TGF- signaling promotes growth and development during early embryogenesis. However, in mature ...
The MICROLAB® NIMBUS is Hamilton Company's newest automated multi-channel pipetting platform, offering a high density deck layout in a body small enough ...
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