Rules-Based Medicine Rules-Based Medicine (RBM) is a CLIA-certified biomarker testing laboratory specializing in cost-effective, high-quality multiplexing services. Our protein immunoassays benefit drug discovery & development from...
Kent Scientific For over 20 years, Kent Scientific Corporation has been serving medical and research scientists as a worldwide provider of integrated solutions for pre-clinical research and drug discovery advancement. You can choose from...
The Jackson Laboratory We help researchers discover treatments, preventions and cures for human disease through the provision of inbred, mutant and genetically engineered mouse models, research services, and comprehensive technical information...
Aged Mice
In some mouse models, a disease condition develops only with age. JAX will maintain your research strain, or any JAX® Mice strain, and deliver mice to you...
Cryopreserved Mouse Embryos
Each embryo shipment contains enough embryos to recover a minimum of two pairs of mice, one mouse of each pair being a carrier animal. A detailed recovery...
Cryorecovery
Sperm Cryorecovery
Sperm cryopreservation using the published JAX method enables strains to be quickly, reliably and cost-effectively recovered. A standard...
Embark Scientific Embark Scientific provides Clinical and Pre-clinical Assay Development, High throughput Sample Processing, Laboratory Animal Genetics, mouse genotyping and Health Monitoring, Research-based development and testing...
Taconic Taconic is dedicated to developing and delivering animal models and related laboratory services for the biomedical research community. We work closely with researchers to assure the integrity of their studies by...
Epidemiologic analysis has revealed the association of psoriasis with inflammatory bowel disease (IBD) in humans. In mice, transfer of CD45RBhi CD4+ naive T cells into immunodeficient animals induces colitis and psoriasis-like phenotypes. This sample study describes the utility of such an adoptive transfer model to evaluate novel compounds for the treatment of IBD and psoriasis.
Transforming growth factor- (TGF-), a member of the TGF superfamily of proteins that includes activins, inhibins, and bone morphogenetic proteins (BMPs), regulates a wide array of cellular processes including cell differentiation, cellular senescence, immune response, wound healing, and apoptosis. TGF- signaling promotes growth and development during early embryogenesis. However, in mature ...
Cyclooxygenases (COXs), also known as prostaglandin H synthases, are fatty acid oxygenases that contain about 600 amino acid residues and act on arachidonic acid to generate prostaglandins (PG). All vertebrates contain two COX genes: one encoding the constitutive COX-1 and another inducible COX-2. COX-1 and COX-2 share approximately 60-65% amino acid identity. These COX isoforms are bifunctional ...
In unstressed cells, p53 is latent and is maintained at low levels by targeted degradation mediated by MDM2. Through its binding to p53, MDM2 can shuttle p53 out of the nucleus into the cytoplasm for degradation. When normal mammalian cells are subjected to stress signals, such as hypoxia, radiation, and chemotherapeutic drugs, p53 is phosphorylated at multiple sites, including those involved in ...
Telomerase is a specialized ribonucleoprotein composed of telomerase reverse transcriptase (TERT), an intrinsic RNA template (TR), and several associated proteins. Its main function is to stabilize telomeres, which protect chromosomes from recombination and end-to-end fusion.
Telomeres also recognize DNA damage and control the replicative capability of cells. With each cell division some of ...
The MICROLAB® NIMBUS is Hamilton Company's newest automated multi-channel pipetting platform, offering a high density deck layout in a body small enough ...
Affordable semi-automated (Click’n’Count) and automated (SuperCount), the aCOLyte colony counting systems greatly improve efficiency, reliability and ...
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