NuAire Inc. Choose NuAire for Ergonomic Laboratory Equipment; Biological Safety Cabinets, CO2 Incubators, Ultra Low Freezers, Laminar Airflow, Animal Handling, and more.
Centrifuges.com Centrifuges.com specializes in complete range of Basic and High end Centrifuges and their accessories, used in diverse fields ranging from academic & scientific research to industrial, medical & other R&D applications....
The Drucker Company The Drucker Company continues the tradition of providing quality centrifuges. With little more than a vision and determination, Ken Drucker purchased the Phillips Company, a St. Louis, Missouri instrument repair company,...
GMI Inc New Used Rectified Clinical, Biotech, Analytical laboratory instrumentation parts GMI Certified Service
Beckman Coulter, Inc Beckman Coulter develops, manufactures and markets products that simplify, automate and innovate complex biomedical testing. Their diagnostic systems are found in hospitals and other critical care settings around the...
Beckman Centrifuges
Beckman Coulter has been at the forefront of centrifuge innovation since we introduced the first commercial ultracentrifuge in 1947. Beckman Coulter General...
Harlow Scientific Harlow Scientific is a purchaser and seller of high quality, reliable scientific and laboratory equipment. We are dedicated to providing excellent customer service to scientists.
Special Projects International Special Projects International, Inc. buys, sells, consigns and brokers quality surplus processing and packaging machinery for the chemical and food industries.
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Cole-Parmer Since 1955, Cole-Parmer has been a leading global source of laboratory and industrial fluid handling products, instrumentation, equipment, and supplies. We are proven experts in the fields of temperature measurement and...
sBench Corporation sBench is an online retailer of laboratory equipment, analytical instruments, consumables and supplies for the life and physical sciences.
Biolog Inc. Biolog is a world leader in cell-based phenotypic testing technologies and assays. We have focused our efforts on developing technologies and products to test properties of cells (phenotypes) very simply and efficiently.
Scientific Asset Management Laboratory, Equipment, Benches, Hoods, Sequencers, Synthesizers, Robotics, Spectrophotometers, Chromatography, fermentors, and many more. If not listed please contact us and we will gladly assist. Evaluations to buyouts...
Analytical ultracentrifugation is a classical technique that has played a critical role in laying the foundations for modern molecular biology. Among its achievements is the demonstration that proteins are macromolecules rather than complexes of smaller units, and direct support for the semi- conservative replication mechanism of DNA as proposed by Watson and Crick. Unlike techniques such as SDS ...
Analytical Ultracentrifugation as a Contemporary Biomolecular Research Tool
Analytical ultracentrifugation has again become a widely used biomolecular research technique for determining sample purity, characterizing assembly and disassembly mechanisms of biomolecular complexes, determining subunit stoichio-metries, detecting and characterizing macromolecular con-formational changes, and ...
Determination of the assembly state(s) of a membrane protein poses a difficult analytical problem. Examine a powerful technique that is well adapted to meet this challenge; interaction analysis using analytical ultracentrifugation. Due to their hydrophobic nature, membrane proteins require detergent (or lipid) for solubilization in solution. Thus, a fundamental obstacle to be overcome in ...
Introduction The Optima XL-A/XL-I Data Analysis Software from Beckman includes a program in the Utilities section that synthesizes equilibrium data according to parameters set by the user. This article will de- scribe and define the parameters available to the user and the graphics associated with the software. A simple monomer-dimer reversible self-associating system will be used as a model to ...
How to Create a Valuable Testing Approaches for prtotein-ligand interactions. The non-covalent binding of small molecules, ligands to proteins or proteins to proteins, plays a crucial role in biopharmaceutical research. This interaction can alter the stereochemistry of a protein molecule (a drug candidate) and also could modify its molecular recognition ability and ultimately its bioactivity. ...
The analytical ultracentrifuge permits observations of the behavior of macromolecules subjected to a centrifugal field. Such experiments permit determi- nation of solution molecular weights, association constants, and studies of homogeneity, shape, and other molecular parameters. The instrument consists of a centrifuge and a rotor with a windowed sample compartment, so that the distribution of ...
Introduction We have studied the dimerization of -chymot- rypsin as an example of a typical self-associating system in order to show how such a reaction may be characterized. -Chymotrypsin has also been sug- gested as a model system to ensure the proper opera- tion of the analytical ultracentrifuge. An ideal model system should be a well-charac- terized association where a single equilibrium ...
The fundamental measurement in any analytical ultracentrifuge experiment is the concentration as a function of radial position. The Optima™ XL-I 1 of- fers two optical systems for determining the concen- tration distribution. The first is the absorbance op- tics, which provide greater selectivity and sensitivity. The second is the Rayleigh interference2 optical sys- tem, which provides great ...
One of the latest attempts to improve monoclonal antibodies in their use as radiolabeled diagnostic markers (1) has involved the cross-linking of novel Fab' fragments. It is expected that a relationship exists between the spacing of the antigen binding sites at the extremes of the Fab' frag-ments in solution and their immunological performance in vitro and in vivo. In order to properly understand ...
Spectrophotometric determination of protein con- centrations is an important analytical tool for nearly all phases of protein drug development and manu- facturing. Determinations of absorptivities (A0.1%) and molar extinction coefficients ( ) for protein so- lutions require at least one initial, accurate measure- ment of protein concentration. Traditionally, this crucial concentration has been ...
The SOTAX HT100 Tablet Testing System measures individual tablet weight, thickness and hardness automatically for hundreads of tablets. Simply load in ...
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