Shimadzu Shimadzu is a world leader in the development and manufacture of analytical instruments for a broad range of applications in science and industry
Shim-pack XR Series Columns
The Shim-pack XR Series of high performance liquid chromatography (HPLC) columns delivers high-speed HPLC analysis, balancing the need for increased...
Imtakt Imtakt is developing innovative products for the Life Sciences, as there are novel media and columns for HPLC separations. These products are powerful and crucial keys for analysing complex mixtures, fast. They can meet...
Tosoh Bioscience Tosoh Bioscience manufactures columns, resins and instruments for the liquid chromatography market. With over 30 years of experience our company is recognized as a leader in the HPLC arena with columns and resins for all...
Biotech Support Group LLC. Biotech Support Group offers a range of proteomic services to support new multilevel sub-fractionation strategies, Bio-Seperation, Immobilization, Protein Modification and Protein Interaction.
Biotech Support Group...
ES Industries ES Industries offers the HPLC chromatographer an important source for high performance bonded phases and packing materials. The Chromegabond® materials produced at our New Jersey facility represent the state-of-the-art in...
Restek Corp. Restek is a leading developer and manufacturer of chromatography columns and accessories. We provide analysts around the world with the innovative tools they need to monitor the quality of air, water, soil, foods,...
Arkema Incorporated Arkema is a world-class producer of industrial chemicals, including acrylics, PMMA, thiochemicals, fluorochemicals, and hydrogen peroxide and of performance products like technical polymers, specialty chemical organic...
Ajulemic acid, a non-psychoactive synthetic cannabinoid derivative of 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH), has a chemical structure amenable to high pH conditions for HPLC-tandem mass spectrometric analysis.
The science, art, and practice of protein purification have been with us for more than a century, yet, in many respects,
the field is only now evolving past its adolescent roots. New methods are replacing old methods at such a dizzying
pace, that even life-long experts in protein purification cannot keep up. In this article, we present many state-of-the-art
protein purification techniques ...
Size exclusion chromatography (SEC) is a chromatographic method in which particles are separated based on their hydrodynamic vol- ume. When the separation medium is a gel, the technique is known as gel permeation chroma- tography (GPC) or gel filtration chromatogra- phy (GFC). Often the terms SEC and GPC are used interchangeably, while GFC is most often used for aqueous chromatography. ...
Amlexanox is used in the treatment of minor aphthous ulcers (canker sores). A specific HPLC-FL assay method for the determination of amlexanox in human serum was therefore developed and validated according to the current industry guidelines.1 The calibration range for the method is 5-250 ng/mL.
Caffeine and its metabolites are ubiquitous in human biological fluids due to dietary consumption. The metabolites of caffeine are paraxanthine, theobromine and theophylline. The ratio of paraxanthine to caffeine may serve as a surrogate measurement of liver function, and thus, there is much interest in monitoring these two analytes simultaneously. Often times, the interference of theophylline to ...
Rapid, Sensitive, General-Purpose Cleaning-Verification HPLC Methods Using Fused-Core™ Particle (FCP) Columns on Conventional Instrumentation S. Bannister1, M. Talbott1, F. Hanciles1, R. Henry2 1Xcelience LLC, Tampa, FL; 2Consultant, State College, PA
This work was undertaken to investigate the use of rapid gradients using recently introduced FCP columns on conventional instrumentation in the ...
Purpose. In order to increase the sample throughput of a manual LC-FL assay for ketoconazole, the method was automated and a multiplexed HPLC system was employed.
Methods. The original ketoconazole method involved manual protein precipitation, followed by HPLC-FL analysis with a run time of approximately 15 minutes. The sample preparation was converted to the 96 well format and automated using ...
Ribavirin is an antiviral prodrug used for the treatment of Hepatitis C and respiratory syncytial virus (RSV) among other common viruses. A method for the analysis and quantification of ribavirin in rat plasma utilizing HPLC-MS/MS with updated HPLC column technology has been developed and validated according to the FDA guidance to the industry.
The assay displays good linearity with ...
To perform a head to head linearity comparison of the Finnigan TSQ 7000 and the Sciex API 3000 LC/MS/MS systems. Methods: An LC/MS/MS assay based on solid phase extraction was developed for a proprietary new chemical entity and its metabolite in human plasma. Initially, the assay was validated on the Finnigan TSQ 7000. The assay linearity on the Finnigan was assessed by analyzing 6 replicates of ...
Pioglitazone is a prescription drug of the class thiazolidinedione with hypoglycemic (antihyperglycemic, antidiabetic) action and is used for the treatment of diabetes mellitus type 2 in monotherapy. It is usually administered in combination with sulfonylurea, metformin, or insulin. Pioglitazone is typically assayed with traditional LC-MS/MS methodologies. Here we present validation data for ...
The MICROLAB® NIMBUS is Hamilton Company's newest automated multi-channel pipetting platform, offering a high density deck layout in a body small enough ...
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