Hitachi High Technologies America, Inc. The Life Science Group of Hitachi High Technologies America, Inc. (HTA) assists researchers in finding solutions to their scientific instrument requirements. We are committed to providing the highest quality scientific...
Waters Corporation Waters Corporation, (NYSE:WAT), creates business advantages for laboratory-dependent organizations by delivering practical and sustainable innovation in the areas of liquid chromatography and mass spectrometry, two vital...
Dionex Dionex Corporation develops, manufactures, sells, and services chromatography and extraction systems for separating, isolating, and identifying the components of chemical mixtures.
Our continuing leadership in...
ChainLink Research, Inc. The company was founded in the year 2003.ChainLink Research has quickly established its growing influence and thought leadership in Supply Chain Management.The company is one of the most widely respected Research and...
Werum Software & Systems America, Inc. Werum Software & Systems is the worldwide leading supplier of Manufacturing Execution Systems (MES) for the pharmaceutical and biopharmaceutical industries.In December 2000, Werum founded Werum America, Inc. in...
Xyntek Incorporated Xyntek, Inc. was founded in 1986 by a group of Real-Time Automation & System Solution Engineers. Xyntek, Inc. is a Global Leader in Real-Time IT and Industrial Automation solutions. Xyntek, Inc. continues to be one of...
A sensitive and specific LC-MS/MS method was developed for the quantitation of 7-hydroxycoumarin, resorufin, hydroxytolbutamide, 4' hydroxymephenytoin, 6ß- hydroxytestosterone, dextrorphan, 6-hydroxychlorzoxazone and 12-hydroxylauric acid metabolites generated by cytochrome P450 enzymes using standard probe substrates.
The analysis was conducted using a calibration curve prepared by fortifying ...
An HPLC-MS/MS method was developed and validated for rifabutin in plasma with a linear range of 5.00 to 800 ng/mL. Rifabutin is a semisynthetic antibacterial agent for use against diseases such as Mycobacterium-avium complex in HIV-positive patients. The HPLC-MS/MS method developed was validated for the determination of rifabutin in human plasma.
Budesonide is an anti-inflammatory, synthetic corticosteroid used for the treatment of asthma by oral inhalation.The objective was to validate a sensitive and specific HPLC-MS/ MS assay to determine budesonide in human plasma for support of Sheffield Pharmaceutical clinical trials. An automated 96-well HPLC-MS/MS assay method for the determination of budesonide in human plasma was therefore ...
Today’s industrial data acquisition generally takes place in real time. The conditions and process environments of measured values regarding room climate change slowly, but are, nevertheless, permanent. Therefore, modern data recording systems that are implemented in this indust ry have to be reliable like Lufft products. Our products feature the following characteristics: modular design, a ...
Erythromycin is a known CYP3A4 inhibitor and is used in the investigation of potential drug-drug interactions in clinical studies.1 A specific HPLC-MS/MS assay method for the determination of erythromycin in human plasma was developed and validated according to the current industry guidelines.
DASGIP develops and manufactures technologically advanced Parallel Bioreactor Systems for the cultivation of microbial and mammalian cells at bench top scale. www.dasgip.com
o Parallel operation of 4, 8 or more vessels o Suitable for cell cultivation and microbial fermentation o Control hardware optimized for small scale process development o Hard- and software designed for efficient parallel ...
Previously, four HPLC-MS/MS methods using two columns with multiple injections were used to monitor nine CYP P450 Isozyme activities (Method I). Using this method was not efficient or cost effective. Therefore one optimized HPLC-MS/MS method (two ionization modes) was developed to monitor the activities of all nine Isozymes (Method II).
Frozen pooled (male and female) human liver microsomes ...
Amlexanox is used in the treatment of minor aphthous ulcers (canker sores). A specific HPLC-FL assay method for the determination of amlexanox in human serum was therefore developed and validated according to the current industry guidelines.1 The calibration range for the method is 5-250 ng/mL.
Rapid, Sensitive, General-Purpose Cleaning-Verification HPLC Methods Using Fused-Core™ Particle (FCP) Columns on Conventional Instrumentation S. Bannister1, M. Talbott1, F. Hanciles1, R. Henry2 1Xcelience LLC, Tampa, FL; 2Consultant, State College, PA
This work was undertaken to investigate the use of rapid gradients using recently introduced FCP columns on conventional instrumentation in the ...
Profiling of impurities in biopharmaceuticals and their associated intermediates and excipients is a regulatory expectation. Since residuals are typically present at low levels in difficult sample matrices, development and validation of assays can be quite challenging. Matrix types can vary greatly due to the fact that sampling at a variety of process steps is required to accurately monitor ...
StudyManager Sponsor Edition (SE) dramatically improves study performance with real-time interaction and clinical data collection for pharmaceutical and ...
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