Charles River Laboratories For more than 60 years, Charles River has provided tailored research models and laboratory animal support services, as well as preclinical and clinical services, to help our global partners accelerate their research and...
Bachem Bachem is an independent, technology-based, public biochemicals company providing full service to the pharma and biotech industry. Bachem is specialized in the process development and the manufacturing of peptides and...
IMAS Corp. IMAS Corporation has the solution for your Specification Document Management needs. The Xspec Solution will enable your organization to eliminate all current disparate specification and document systems, thus giving you...
Compliance Net ComplianceNet, Inc. provides a wide variety of services to help companies meet international regulatory challenges. Consultants specialize in guiding small, start-up firms to establish efficient, cost effective and...
PharmaSys PharmaSys combines proven experience in system compliance and validation with extensive knowledge of scientific and laboratory processes.
*Audits - PharmaSys provides third party cGMP, GLP and GCP compliance audits as...
Whereas 10 years ago no one thought about placing GLP-compliant preclinical studies in China, soon every biopharma company preparing an IND will take China into account, where GLP study costs are lower, studies can often start sooner, and access to animal models is easier. Right now, however, with GLP studies in China so new, companies considering China have many questions. For example, “Can ...
Telomerase is a specialized ribonucleoprotein composed of telomerase reverse transcriptase (TERT), an intrinsic RNA template (TR), and several associated proteins. Its main function is to stabilize telomeres, which protect chromosomes from recombination and end-to-end fusion.
Telomeres also recognize DNA damage and control the replicative capability of cells. With each cell division some of ...
Cyclooxygenases (COXs), also known as prostaglandin H synthases, are fatty acid oxygenases that contain about 600 amino acid residues and act on arachidonic acid to generate prostaglandins (PG). All vertebrates contain two COX genes: one encoding the constitutive COX-1 and another inducible COX-2. COX-1 and COX-2 share approximately 60-65% amino acid identity. These COX isoforms are bifunctional ...
Transforming growth factor- (TGF-), a member of the TGF superfamily of proteins that includes activins, inhibins, and bone morphogenetic proteins (BMPs), regulates a wide array of cellular processes including cell differentiation, cellular senescence, immune response, wound healing, and apoptosis. TGF- signaling promotes growth and development during early embryogenesis. However, in mature ...
In unstressed cells, p53 is latent and is maintained at low levels by targeted degradation mediated by MDM2. Through its binding to p53, MDM2 can shuttle p53 out of the nucleus into the cytoplasm for degradation. When normal mammalian cells are subjected to stress signals, such as hypoxia, radiation, and chemotherapeutic drugs, p53 is phosphorylated at multiple sites, including those involved in ...
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