Pharmaceuticals
Research Library
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EMD Chemicals Inc.
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Transforming growth factor- (TGF-), a member of the TGF superfamily of proteins that includes activins, inhibins, and bone morphogenetic proteins (BMPs), regulates a wide array of cellular processes including cell differentiation, cellular senescence, immune response, wound healing, and apoptosis. TGF- signaling promotes growth and development during early embryogenesis. However, in mature ...
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BASInc
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Purpose. In order to increase the sample throughput of a manual LC-FL assay for ketoconazole, the method was automated and a multiplexed HPLC system was employed.
Methods. The original ketoconazole method involved manual protein precipitation, followed by HPLC-FL analysis with a run time of approximately 15 minutes. The sample preparation was converted to the 96 well format and automated using ...
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Hamilton Robotics
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Prediction of the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of compounds in pharmaceutical development are essential aspects of the drug discovery process. B-CLEAR® (sandwich-cultured hepatocytes) is an in vitro system that is used to analyze and predict the in vivo hepatobiliary disposition (hepatic uptake, biliary excretion, and biliary clearance) and ...
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United States Biological
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Immunohistochemistry is widely used in basic research to understand the distribution and localization of biomarkers and differentially expressed proteins in different parts of a biological tissue. IHC staining is also widely used in the diagnosis of abnormal cells such as those found in cancerous tumors. Visualizing an antibody-antigen interaction can be accomplished in a number of ways. In the ...
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Parameter Generation & Control, Inc.
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On the surface, providing a specified humidity and temperature for stability testing may appear easier to achieve than the 5% RH and 2C ICH guidelines would seem to indicate. The ability to control humidity at 2% does not mean that you are safely within the 5% RH tolerance dictated by ICH.
The ability to produce a recording, display, or printout that is within a specified tolerance may not be a ...
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