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p53 and MDM2: Partners in Repair and Death
EMD Millipore Bioscience
In unstressed cells, p53 is latent and is maintained at low levels by targeted degradation mediated by MDM2. Through its binding to p53, MDM2 can shuttle p53 out of the nucleus into the cytoplasm for degradation. When normal mammalian cells are subjected to stress signals, such as hypoxia, radiation, and chemotherapeutic drugs, p53 is phosphorylated at multiple sites, including those involved in ...
 
Targeting PK and Patient Needs with Versatile, Timed-Based Oral Drug Delivery
Aptalis Pharmaceutical Technologies
In 2009 more than one-half of the drug candidates going beyond Phase 2 development were line extensions or modifications of existing products, rather than representing truly innovative new molecules, according to a 2010 annual report from the consultancy firm CMR International, a Thomson Reuters business [1]. Clearly, pharmaceutical developers pursue product opportunities that meet patients’ ...
 
Regulatory Overview of Antimicrobial Products Bearing Public Health Claims
ATS Labs
Antimicrobial products intended to protect the public health are regulated as pesticides in the United States by the Environmental Protection Agency (EPA). Before manufacturers can sell pesticides in the United States, EPA must evaluate the pesticides thoroughly to ensure that they meet federal safety standards to protect human health and the environment. This white paper, featuring a convenient ...
 
How to measure porosity of bone
Quantachrome Instruments
Pycnometers Aid Osteoporosis and Bioscaffold Research It is possible to measure the porosity of bone and small bioceramic or scaffold samples with remarkable accuracy, speed and ease using gas pycnometry [1, 2], Furthermore, using the optional Nanocell, the volume of hydroxyapatite, i.e. the true mineral volume of a very small sample (~0.2cc) of biopsied bone, suitably prepared , can be ...
 
Imaging Chemiluminescence by Scanning
LI-COR Biosciences
Enhanced chemiluminescence (ECL) is widely used for detection of target proteins on Western blots. For detection, horseradish peroxidase (HRP) enzyme is typically conjugated to a secondary antibody.The en- zyme causes oxidation of the luminol-based chemiluminescent substrate, creating an excited state prod- uct. As this product decays to a lower energy state, it transiently produces light (Fig. ...
 
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Clinical Trial Portal ePharmaSolutions Short Demonstration of ePharmaSolutions' award winning Clinical Trial Portal and intergrated eTMF (Electronic Trial Master File).
 
PB100001 Union Standard Equipment
 

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