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Pharmaceuticals
Research Library
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Emerald Bio
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Myriad RBM, Inc.
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MINIMIZING Rheumatoid Factor Interference in Myriad RBM's Biomarker Assays
Introduction The reduction or elimination of non-specific sources of interfering signals is a critical component of any clinical study relying on the measurement of biomarkers using immunoassays. Interference often arises from heterophile antibodies – antibodies which are relatively non-specific and exhibit broad ...
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EMD Millipore Bioscience
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In unstressed cells, p53 is latent and is maintained at low levels by targeted degradation mediated by MDM2. Through its binding to p53, MDM2 can shuttle p53 out of the nucleus into the cytoplasm for degradation. When normal mammalian cells are subjected to stress signals, such as hypoxia, radiation, and chemotherapeutic drugs, p53 is phosphorylated at multiple sites, including those involved in ...
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Inova Software
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In 2001, I-Nova Software was founded to provide “innovation management” solutions – both software and services – to large companies. Over the years, we have observed an interesting pattern emerging among our clients: The migration of “innovation” from a metric within specific departments, to the creation of a dedicated Innovation function at the corporate level.
During our first few years of ...
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Capsugel
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The BCS attempts to identify when dissolution rate is likely to be rate-determining, and to assess when in-vitro/in-vivo correlations would be ex- pected. And that would be, of course, the Class I type of drug, where dissolution is rapid and not the rate-determining step, plasma levels may not reflect product differences, and little or no difference would be expected between oral solutions and ...
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