Pharmaceuticals
Research Library
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EMD Chemicals Inc.
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In unstressed cells, p53 is latent and is maintained at low levels by targeted degradation mediated by MDM2. Through its binding to p53, MDM2 can shuttle p53 out of the nucleus into the cytoplasm for degradation. When normal mammalian cells are subjected to stress signals, such as hypoxia, radiation, and chemotherapeutic drugs, p53 is phosphorylated at multiple sites, including those involved in ...
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Quintiles Transnational
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There is plenty of discussion in the biopharma industry about declining R&D productivity, increasing development costs, diminishing returns on marketing and sales, and lower earnings. And the “patent cliff” that is quickly approaching will only increase pressure on biopharma players. From 2009 through 2014, an estimated $128 billion of branded revenues will lose patent protection and face generic ...
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BioClinica, Inc.
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Global clinical trial solutions. Real-world results.
In the wake of the recent spate of drug withdrawals and other drug safety issues, there have been renewed calls to reform and enhance the U.S. approach to monitoring safety issues in marketed products. These calls have come from many quarters, and a variety of initiatives have been the result. This article briefly summarizes the current ...
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Kinapse
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Practical Approaches to Early Stage Life Sciences Technology Valuations
With fierce competition in the market for late stage life sciences assets, pharmaceutical companies seeking partnering strategies to bolster pipelines and drive long-term revenues are increasingly looking towards earlier stage compounds and technologies.
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Labconco Corp.
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Safety is the primary purpose of any filtered enclosure or ventilated fume hood. In most situations, fume hoods re- main the equipment of choice for ventilating hazardous air- borne chemicals from the laboratory. However, there are applications where a ductless enclosure or ductless hood provides convenience and flexibility beyond what a tradi- tional fume hood offers. For example:
Ductless ...
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